Assessment of lipid profile among diabetic and non-diabetic subjects with and without khat chewing habit, in Adama, Ethiopia
No Thumbnail Available
Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background: The problem of dyslipidemia is high in patients with diabetes mellitus. There is
known evidence that abnormalities in lipid metabolism are important risk factors for increased
incidence of diabetes associated complications. The most important risk indicators for these
complications are lipid profile abnormalities. Very few published papers have tried to draw a
conclusion about khat chewing and it effect on lipid level. However, the influence of chewing
khat on the lipid profile and dyslipidaemia is insufficiently investigated
Objective: This study aimed to assess lipid profile among diabetic and apparently healthy
subjects with and without khat chewing habit.
Method: a comparative crossectional study was conducted in Adama. A total of 220(118 DM
and 102 apparently healthy) study subject were included. Convenience sampling methods were
used. Basic anthromotric and demographic data was collected using structured questionnaires.
And Serum Lipid profile was measured using Cobas 311 automated clinical chemistry analyzer
at Adama hospital. Data were analyzed statistically using spss version 20.0. Independent t test
were used to compare the means of lipid profile among two groups and logistic regression is
used to associate lipid profile parameter with different independent variables. P-value<0.05 at
95% confidence interval (CI) was considered as statistically significant.
Result: The results showed that the mean serum levels of TC =227.33mg/dl, HDL-C =
28.4mg/dl, TG =164.2mg/dl and LDL-C = 112.48mg/dl in khat chewers diabetic subject, while
TC =178.4mg/dl, HDL-C = 35.96 mg/dl, TG =160.1 mg/dl and LDL-C = 109.02 mg/dl in non
khat chewer diabetic subject. The difference for TC and HDL-C are statistically significance.
The mean serum levels of TC, LDL-C, HDL and TG are (154.23 mg/dl), (86.33 mg/dl), (41.1
mg/dl) and (95.44 mg/dl) respectively in non-diabetic khat chewer while the TC, LDL-C, HDL
and TG (149.3 mg/dl), (85.45 mg/dl), (43.28 mg/dl) and (90.5 mg/dl) in non-diabetic non khat
chewer respectively. And the difference is statistically not significance:
Conclusion: Dyslipidemia is more prevalent in diabetics particularly in those with khat chewing
habit. Thus, Khat has unfavorable side effects on the level of lipid profile.
Recommendation: Health education about the adverse effect of khat chewing on DM should be
delivered to the community and healthy institution using available forum
Description
Keywords
Diabetic ,non-diabetic ,khat