Assessment of lipid profile among diabetic and non-diabetic subjects with and without khat chewing habit, in Adama, Ethiopia

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Addis Abeba University


Background: The problem of dyslipidemia is high in patients with diabetes mellitus. There is known evidence that abnormalities in lipid metabolism are important risk factors for increased incidence of diabetes associated complications. The most important risk indicators for these complications are lipid profile abnormalities. Very few published papers have tried to draw a conclusion about khat chewing and it effect on lipid level. However, the influence of chewing khat on the lipid profile and dyslipidaemia is insufficiently investigated Objective: This study aimed to assess lipid profile among diabetic and apparently healthy subjects with and without khat chewing habit. Method: a comparative crossectional study was conducted in Adama. A total of 220(118 DM and 102 apparently healthy) study subject were included. Convenience sampling methods were used. Basic anthromotric and demographic data was collected using structured questionnaires. And Serum Lipid profile was measured using Cobas 311 automated clinical chemistry analyzer at Adama hospital. Data were analyzed statistically using spss version 20.0. Independent t test were used to compare the means of lipid profile among two groups and logistic regression is used to associate lipid profile parameter with different independent variables. P-value<0.05 at 95% confidence interval (CI) was considered as statistically significant. Result: The results showed that the mean serum levels of TC =227.33mg/dl, HDL-C = 28.4mg/dl, TG =164.2mg/dl and LDL-C = 112.48mg/dl in khat chewers diabetic subject, while TC =178.4mg/dl, HDL-C = 35.96 mg/dl, TG =160.1 mg/dl and LDL-C = 109.02 mg/dl in non khat chewer diabetic subject. The difference for TC and HDL-C are statistically significance. The mean serum levels of TC, LDL-C, HDL and TG are (154.23 mg/dl), (86.33 mg/dl), (41.1 mg/dl) and (95.44 mg/dl) respectively in non-diabetic khat chewer while the TC, LDL-C, HDL and TG (149.3 mg/dl), (85.45 mg/dl), (43.28 mg/dl) and (90.5 mg/dl) in non-diabetic non khat chewer respectively. And the difference is statistically not significance: Conclusion: Dyslipidemia is more prevalent in diabetics particularly in those with khat chewing habit. Thus, Khat has unfavorable side effects on the level of lipid profile. Recommendation: Health education about the adverse effect of khat chewing on DM should be delivered to the community and healthy institution using available forum



Diabetic ,non-diabetic ,khat