Survival and Risk Factors of HIV/Tb Co-Infected Patients Under Antiretroviral Therapy in Ambo Hospital, Ethiopia

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Addis Abeba university


HIV infection is the greatest risk factor for acquiring TB infection and developing TB. TB enhances HIV replication by accelerating the natural evolution of HIV infection and it is the most leading cause of sickness and death of PLWHIV. The objective of this study is to assess the survival and risk factors of HIV/TB co-infected patients in Ambo hospital, west Shoa zone in Oromia regional state, Ethiopia. This is a retrospective study based on cases of HIV-infected TB patients of age 15 years and above who have started anti-TB treatment between September 1, 2006 and August 31, 2011 and followed until February 29, 2012. To analyze the data descriptive statistics, univariate and multivariate analyses were used. The descriptive analysis indicates that out of the total 501 individuals, 79(15.8%) are death cases, of which 31 (39.2%) and 49 (62%) deaths occurred within six and nine months of TB treatment start. The Kaplan-Meier method was used to estimate the survival time and Cox’s regression model was employed to identify the covariates that have a statistical significant effect on the survival of HIV/TB co-infected patients. The estimation of the model parameters was done by partial maximum likelihood procedures. The multivariate analysis of Cox regression model gives that initial weight, TB site, WHO clinical stage, functional status and CD4 count are significant risk factors of survival of HIV/TB co-infected patients. Furthermore the patients with lower initial weight, lower CD4 count, WHO stage III and IV, being ambulatory and bedridden are associated with higher risk of death



Survival and Risk Factors of HIV