Association of Coffee Consumption with Insulin Sensitivity and Plasma Lipid Profile among Non-Diabetic Individuals in Addis Ababa
| dc.contributor.advisor | Chawla, Rajinder(PhD) | |
| dc.contributor.advisor | Umeta, Melaku (PhD) | |
| dc.contributor.advisor | Chawla, Neena(PhD) | |
| dc.contributor.author | Mamo, Gizaw | |
| dc.date.accessioned | 2021-09-30T11:05:19Z | |
| dc.date.accessioned | 2023-11-29T04:18:26Z | |
| dc.date.available | 2021-09-30T11:05:19Z | |
| dc.date.available | 2023-11-29T04:18:26Z | |
| dc.date.issued | 2010-07 | |
| dc.description.abstract | Abstract Background: Coffee is the most consumed beverage in the world and research has attempted to make clear health benefits received from coffee drinking. Type 2 diabetes is one of the diseases that are largely determined by lifestyles factors. The role of coffee in relation to type 2 diabetes and other diseases such as cardiovascular disease, hypertension and neurological diseases in Ethiopia has not been well investigated thoroughly. Objective: The aim of the present study is to investigate the relationship between coffee consumption and insulin sensitivity status among non-diabetic individuals in Addis Ababa. Materials and Methods: A cross-sectional study was conducted in 70 non-diabetic and apparently health individuals in Addis Ababa. The participants were 35 coffee drinkers (16 males; 19 females) and 35 non-drinkers (15 males; 20 females). Data regarding coffee consumption was obtained by using questioners and laboratory analysis. Blood samples were collected for analysis of insulin sensitivity indicators, namely-; serum fasting and post loading glucose and insulin level and serum lipid profile (cholesterol, triglyceride, free fatty acid, high density and low densit y lipoproteins). Results were compared among coffee consumers and non consumers using appropriate statistical parameters Results: Median of serum level of fasting and post-load glucose was 101.2 and 118.8 for coffee drinkers and 101.9 and 120.9 for non-drinkers. These results didn't show statistically significant (P>0.05) difference between the two groups. There was also no significance difference in the fasting (14.8 and 12.7) and post-loading (31.0 and 26.7) of blood insulin level between coffee drinkers and non-coffee drinkers. Similarly, blood level of fasting and post-loading glucose and insulin of noncoffee drinkers were not significantly difference from blood level of fasting and post-load glucose and insulin of the coffee drinkers of men, women, young and not-so young groups. Compared to non-coffee drinkers, coffee drinkers of men (p<0.01, p<0.05), young groups (p<0.05, p<0.05) and not-so young groups (p<0.05, p<0.05) showed significantly increased and decreased in blood concentration of free fatty acid and triglyceride respectively. The ratio of TG to HDL-C was significantly lowered in coffee drinkers. Other parameters were not significantly difference between coffee drinkers and non-drinkers. Conclusion: Significantly higher of blood free fatty acid level in coffee drinkers may indicate that coffee reduces insulin sensitivity. However, non-significantly lower of blood level of triglyceride and LDL-C with higher HDL-C, significantly decrease of the ratio of TG to HDL-C and nonsignificantly lower HOMA analysis for fasting and post-loaded in coffee drinkers may indicate coffee improves insulin sensitivity and has antioxidant activities. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28019 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Coffee,insulin,plasma lipid,non-diabetic individuals | en_US |
| dc.title | Association of Coffee Consumption with Insulin Sensitivity and Plasma Lipid Profile among Non-Diabetic Individuals in Addis Ababa | en_US |
| dc.type | Thesis | en_US |