Association of Coffee Consumption with Insulin Sensitivity and Plasma Lipid Profile among Non-Diabetic Individuals in Addis Ababa
| dc.contributor.advisor | Chawla Rajinder | |
| dc.contributor.advisor | Umeta Melaku | |
| dc.contributor.advisor | Chawla Neena | |
| dc.contributor.author | Mamo Gizaw | |
| dc.date.accessioned | 2021-09-30T11:05:19Z | |
| dc.date.accessioned | 2023-11-29T04:18:26Z | |
| dc.date.available | 2021-09-30T11:05:19Z | |
| dc.date.available | 2023-11-29T04:18:26Z | |
| dc.date.issued | 2010-07 | |
| dc.description.abstract | Background: Coffee is the most consumed beverage in the world and research has attempted to make clear health benefits received from coffee drinking. Type 2 diabetes is one of the diseases that are largely determined by lifestyles factors. The role of coffee in relation to type 2 diabetes and other diseases such as cardiovascular disease, hypertension and neurological diseases in Ethiopia has not been well investigated thoroughly. Objective: The aim of the present study is to investigate the relationship between coffee consumption and insulin sensitivity status among non-diabetic individuals in Addis Ababa. Materials and Methods: A cross-sectional study was conducted in 70 non-diabetic and apparently health individuals in Addis Ababa. The participants were 35 coffee drinkers (16 males; 19 females) and 35 non-drinkers (15 males; 20 females). Data regarding coffee consumption was obtained by using questioners and laboratory analysis. Blood samples were collected for analysis of insulin sensitivity indicators, namely-; serum fasting and post loading glucose and insulin level and serum lipid profile (cholesterol, triglyceride, free fatty acid, high density and low density lipoproteins). Results were compared among coffee consumers and non consumers using appropriate statistical parameters Results: Median of serum level of fasting and post-load glucose was 101.2 and 118.8 for coffee drinkers and 101.9 and 120.9 for non-drinkers. These results didn't show statistically significant (P>0.05) difference between the two groups. There was also no significance difference in the fasting (14.8 and 12.7) and post-loading (31.0 and 26.7) of blood insulin level between coffee drinkers and non-coffee drinkers. Similarly, blood level of fasting and post-loading glucose and insulin of non coffee drinkers were not significantly difference from blood level of fasting and post-load glucose and insulin of the coffee drinkers of men, women, young and not-so young groups. Compared to non-coffee drinkers, coffee drinkers of men Conclusion: Significantly higher of blood free fatty acid level in coffee drinkers may indicate that coffee reduces insulin sensitivity. However, non-significantly lower of blood level of triglyceride and LDL-C with higher HDL-C, significantly decrease of the ratio of TG to HDL-C and non significantly lower HOMA analysis for fasting and post-loaded in coffee drinkers may indicate coffee improves insulin sensitivity and has antioxidant activities. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28019 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Coffee,insulin,plasma lipid,non-diabetic individuals | en_US |
| dc.title | Association of Coffee Consumption with Insulin Sensitivity and Plasma Lipid Profile among Non-Diabetic Individuals in Addis Ababa | en_US |
| dc.type | Thesis | en_US |