Association of Coffee Consumption with Insulin Sensitivity and Plasma Lipid Profile among Non-Diabetic Individuals in Addis Ababa
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Date
2010-07
Authors
Journal Title
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Publisher
Addis Abeba University
Abstract
Abstract
Background: Coffee is the most consumed beverage in the world and research has attempted to
make clear health benefits received from coffee drinking. Type 2 diabetes is one of the diseases that
are largely determined by lifestyles factors. The role of coffee in relation to type 2 diabetes and
other diseases such as cardiovascular disease, hypertension and neurological diseases in Ethiopia
has not been well investigated thoroughly.
Objective: The aim of the present study is to investigate the relationship between coffee
consumption and insulin sensitivity status among non-diabetic individuals in Addis Ababa.
Materials and Methods: A cross-sectional study was conducted in 70 non-diabetic and apparently
health individuals in Addis Ababa. The participants were 35 coffee drinkers (16 males; 19 females)
and 35 non-drinkers (15 males; 20 females). Data regarding coffee consumption was obtained by
using questioners and laboratory analysis. Blood samples were collected for analysis of insulin
sensitivity indicators, namely-; serum fasting and post loading glucose and insulin level and serum
lipid profile (cholesterol, triglyceride, free fatty acid, high density and low densit y lipoproteins).
Results were compared among coffee consumers and non consumers using appropriate statistical
parameters
Results: Median of serum level of fasting and post-load glucose was 101.2 and 118.8 for coffee
drinkers and 101.9 and 120.9 for non-drinkers. These results didn't show statistically significant
(P>0.05) difference between the two groups. There was also no significance difference in the fasting
(14.8 and 12.7) and post-loading (31.0 and 26.7) of blood insulin level between coffee drinkers and
non-coffee drinkers. Similarly, blood level of fasting and post-loading glucose and insulin of noncoffee
drinkers were not significantly
difference from blood level of
fasting
and post-load
glucose
and
insulin of
the
coffee
drinkers of
men,
women, young
and not-so
young groups. Compared to
non-coffee drinkers, coffee drinkers of men (p<0.01, p<0.05), young groups (p<0.05, p<0.05) and
not-so young groups (p<0.05, p<0.05) showed significantly increased and decreased in blood
concentration of free fatty acid and triglyceride respectively. The ratio of TG to HDL-C was
significantly lowered in coffee drinkers. Other parameters were not significantly difference between
coffee drinkers and non-drinkers.
Conclusion: Significantly higher of blood free fatty acid level in coffee drinkers may indicate that
coffee reduces insulin sensitivity. However, non-significantly lower of blood level of triglyceride
and LDL-C with higher HDL-C, significantly decrease of the ratio of TG to HDL-C and nonsignificantly
lower
HOMA analysis for fasting and post-loaded
in coffee drinkers may indicate
coffee
improves insulin sensitivity
and has antioxidant activities.
Description
Keywords
Coffee,insulin,plasma lipid,non-diabetic individuals