Cross-Sectional Study on the Assessment of Dyslipidaemia using Classical lipid profile and Apolipoprotein in Type 2 diabetic patients at the Diabetic Clinic of Tikur Anbessa Specialized Teaching Hospital
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Date
2016-11
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Addis Ababa University
Abstract
Background: Type2 diabetes mellitus and its complication are becoming more prevalent in
Ethiopia. It is estimated that 2-3 % of the population is living with diabetic. No Study is
available in correlation of Apolipoprotein and lipid profile that is relevant in diagnosis and
monitoring of diabetic dyslipidaemia in our local set up. Therefore the current study assessed
the correlation of Apolipoprotein with lipid profile.
Objective: Assessment of Dyslipidaemia using lipidprofile, lipid ratios and Apolipoprotein
value in type 2 diabetic patients who are apparently healthy attending diabetic clinic of the
Tikur Anbessa Specialized Teaching Hospital, Addis Ababa.
Method: A Crossectional study was done during the study period from 15/10/2014 to
24/10/2016.Demographic variables were measured and Dyslipidaemia was assessed from
overnight fasting serum sample by measuring Apolipoprotiens and lipid profile. Degree of
association and/or correlation between Apolipoprotein and classical lipid profile was
evaluated using Spearman, Pearson correlation, independent sample t test , Man Whitney test
and Chi square appropriately. SPSS version 20 software was used and histogram, Box Plot
and Scatter plot was used to display results.
Result: A total of 70 type 2 Diabetic patients were participated in the study. Median age of
the participants was 47(31-64). Dyslipidemia Observed in participants were high TC, low
HDL, high LDL , high TG, low Apo A1, high Apo B100 ,high non HDL and high lipid ratios.
Apo B 100 and Apo A1 are positively associated with LDL and HDL respectively. In addition
lipid ratios had significant positive association with atherogenic lipid parameters and negative
association with anti-atherogenic lipid parameters.
Conclusion: Apolipoprotein A1 and B100 are associated with classical lipid profiles that help
in diagnosis of dyslipidaemia in type 2 Diabetic patients
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Diabetic Clinic, Tikur Anbessa Specialized Teaching Hospital