Outcome of Patients with Non Hodgkin’s Lymphoma and its Predictors, at Tikur Anbessa Specialized Hospital: a Retrospective Chart Review, Addis Abeba, Ethiopia, 2019.
No Thumbnail Available
Date
2019-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
Background: Non- Hodgkin’s Lymphoma is the common hematological malignancy, which originates from lymphatic and immune systems; including lymphocytes and lymph nodes. In Ethiopia Non- Hodgkin’s Lymphoma, ranked as 5th most prevalent and 10th deadliest cancer, none the less there is lack of adequate information on the outcomes of patients with Non- Hodgkin’s Lymphoma and its predictors. Objective: this study aims to assess Outcome of patients with non Hodgkin’s lymphoma and its predictors, at Tikur Anbessa Specialized Hospital: a retrospective chart review; Addis Ababa, Ethiopia, 2019.
Methods: Institutional based Retrospective Chart Review study was conducted among patients with Non- Hodgkin’s Lymphoma admitted to Tikur Anbessa Specialized Hospital, Hematology unit. Population censes was used to extract data from 71 adult patient charts from February to April 2019. The data were coded and analyzed by using SPSS version 20 and Cox Hazard regression model was used to calculate the substantial association between the dependent and independent variables, while Kaplan–Meier Log-rank model was used to estimate the survival time of patients after Non- Hodgkin’s Lymphoma diagnosis.
Result: A total of 71 patients were analyzed. The overall five year survival from Non- Hodgkin’s Lymphoma was 32.1%with the median survival of 27 months, 95% CI, [21.98-32.01]. Advanced age, Neutrophil count, monocyte count and Lymphocyte count predicted the outcome of Non- Hodgkin’s Lymphoma dependently on the bivariate analysis. While relapse, advanced stage, Charlson Comorbidity index ≥3, lymphocyte monocyte ratio <3.1, neutrophil lymphocyte ratio (>2.8), and elevated lactate ≥ 245 predicted mortality independently; whereas only platelet lymphocyte ratio ≥144 was found to be independent predictor of good prognosis on multivariate analysis.
Conclusions and recommendations: Generally, the prognosis of Non- Hodgkin’s Lymphoma patents was found to be poor; compared to outcomes in the developed world. So, more emphasis should be given to non communicable diseases along with palliative and end of life care on the health policy.
Description
Keywords
Non- Hodgkin’s Lymphoma, predictor, outcome