Prevalence of H.Pylori Infection in Pediatric Patients Who is Clinically Diagnosed for Gastroenteritis in Beham Specialized Children S Higher Clinic, Addis Ababa, Ethiopia
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Date
2014-05
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Addis Ababa University
Abstract
Background: The public health impact of Helicobacter pylori (HP) infection is gradually
becoming obvious, the bacterium now being implicated as an aetiologic agent in a variety of
gastric diseases. In developing countries, Hp infection is markedly more prevalent at younger
ages than in developed countries. According to World Gastroenterology Organisation (WGO)
2010 the prevalence of HP in Ethiopia was 48% in age between 2 4, 80% at the age of 6
and
95% in adult s population.
Objective: To determine the prevalence of H.pylori infection among paediatric patients who s
clinically diagnosed for gastroenteritis.
Method: A cross sectional study was conducted to determine the prevalence of H.pylori
infection among pediatric patient in private pediatric clinic, Addis Ababa Ethiopia. The study
was conduct from March 3rd to May 11th 2014. Non-probability convenient sampling technique
was used to collect the data. The stool samples were tested according to the manufacture
instruction and procedure. Information from the laboratory analysis and questionnaires were
entered into SPSS, version.17 and odd ratio, 95%CI were calculated to measure the degree of
relationship between risk factors for H. pylori infection.
Result: A total of two hundred twenty one paediatric patients having upper gastrointestinal
symptoms because of a suspicion of H. pylori infection participated in this prospective study at
Beham specialized children s higher clinic between March 2014 and May 2014.Among the
study subjects 114(51.6%) were girls and 107 (48.4%) were boys aged from 9months to
15years with the mean age of 6.29 [95% CI 5.9-6.7]. Helicobacter pylori antigens were
detected in 57 of the 221children giving an overall prevalence of 25.8% (95%CI 18.8-31),
27.2% in female and 24.3% in male children. The frequency of H. pylori colonization was
higher in females than in males. Of the 114 females enrolled in the study, H. pylori antigen was
detected in the stools of 31 (27.2%) against 26 (24.3%) of the 107 males (OR = 0.85
95%CI=0.46-1.57). Age of acquisition was one year and five month.
Conclusions:
The prevalence of H. pylori infection is 25.8%. This is high among children in the study area.
Infection also is acquired at very early age. Household crowding is one of the factors that
enhance the infection.
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Keywords
Children;Pediatric Patients