Prevalence of H.Pylori Infection in Pediatric Patients Who is Clinically Diagnosed for Gastroenteritis in Beham Specialized Children S Higher Clinic, Addis Ababa, Ethiopia
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Date
2014-05
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Addis Ababa University
Abstract
Background: The public health impact of Helicobacter pylori (HP) infection is graduallybecoming obvious, the bacterium now being implicated as an aetiologic agent in a variety ofgastric diseases. In developing countries, Hp infection is markedly more prevalent at youngerages than in developed countries. According to World Gastroenterology Organisation (WGO)2010 the prevalence of HP in Ethiopia was 48% in age between 2 4, 80% at the age of 6and95% in adult s population.
Objective: To determine the prevalence of H.pylori infection among paediatric patients who sclinically diagnosed for gastroenteritis.
Method: A cross sectional study was conducted to determine the prevalence of H.pyloriinfection among pediatric patient in private pediatric clinic, Addis Ababa Ethiopia. The study was conduct from March 3rd to May 11th 2014. Non-probability convenient sampling techniquewas used to collect the data. The stool samples were tested according to the manufactureinstruction and procedure. Information from the laboratory analysis and questionnaires wereentered into SPSS, version.17 and odd ratio, 95%CI were calculated to measure the degree ofrelationship between risk factors for H. pylori infection.
Result: A total of two hundred twenty one paediatric patients having upper gastrointestinal symptoms because of a suspicion of H. pylori infection participated in this prospective study at Beham specialized children s higher clinic between March 2014 and May 2014.Among the study subjects 114(51.6%) were girls and 107 (48.4%) were boys aged from 9months to15years with the mean age of 6.29 [95% CI 5.9-6.7]. Helicobacter pylori antigens weredetected in 57 of the 221children giving an overall prevalence of 25.8% (95%CI 18.8-31),27.2% in female and 24.3% in male children. The frequency of H. pylori colonization washigher in females than in males. Of the 114 females enrolled in the study, H. pylori antigen wasdetected in the stools of 31 (27.2%) against 26 (24.3%) of the 107 males (OR = 0.8595%CI=0.46-1.57). Age of acquisition was one year and five month.
Conclusions:The prevalence of H. pylori infection is 25.8%. This is high among children in the study area.Infection also is acquired at very early age. Household crowding is one of the factors thatenhance the infection.
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Children;Pediatric Patients