Comparison of Fasting blood glucose level among khat chewers and non-khat chewers in diabetics and healthy individuals at Hiwot Fana Specialized University Harar Eastern Ethiopia.
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Date
2020-06
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Addis Abeba University
Abstract
Background: -Khat chewing is a widely heled practice in our society. Moreover, studies about
khat chewing effect are contradictory. There is limited data about khat effect on blood glucose
specially in our setting. Therefore, this study aims to investigate this issue.
Objective: In this study, we compared FBS among khat chewer and khat chewer diabetic and
healthy subjects.
Method: A cross-sectional study include 200 confirmed diabetic and healthy subjects grouped in
to four groups (diabetic khat chewers n=50, diabetic non khat chewer n=50, healthy khat chewer
n=50 and healthy non-khat chewer n=50). FBS was determined by enzymatic method (GOD&G
HK) using Biosystem A25 and COBAS 6000 chemistry analyzers at Hiwot Fana and St. Peter
hospital clinical chemistry laboratory respectively. Non-parametric tests Mann-Whitney test (2independent
sample test) and Kruskal-Wals test (K-independents sample test) were used to
compare fasting blood glucose among khat chewer and non-khat chewer with in the groups and
between groups respectively. P<0.05 is taken to be statistically significant.
Result: - Of the total respondents 83(41.5%) and 117(58.5%) were male and female respectively.
Without age and gender adjustment the overall Median±IQR FBS difference among khat chewers
and non-khat chewers were (159.5±83) mg/dl and (202±79) mg/dl respectively in diabetic patients
using GOD. Similarly, when we compare between healthy non-khat chewers and khat chewers,
khat chewers have lower (Median±IQR) fasting blood glucose level (82±18) mg/dl than that of the
non-khat chewers (94±13) mg/dl when tested by GOD. Generally, there was significantly lower
blood glucose level measured by both GOD and GHK methods in both diabetics and healthy
groups of khat chewers. There was also percentage difference of median FBS with in the same
group when measured by GOD and GHK methods.
Conclusion and recommendation: -There was significant effect of khat on blood glucose level
among khat chewer and non-khat chewer in diabetic and healthy individuals. Based on the present
study finding, further studies have to be conducted to identify khat constituent associated with
hypoglycemic effect and further elucidate khat effect on systemic metabolism.
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Keywords
Khat chewing, serum fasting glucose level