Comparison of Fasting Blood Glucose Level among Khat Chewers and Non-Khat Chewers in Diabetics and Healthy Individuals at Hiwot Fana Specialized University Harar Eastern Ethiopia.
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Date
2020-06
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Addis Abeba University
Abstract
Background: -Khat chewing is a widely heled practice in our society. Moreover, studies aboutkhat chewing effect are contradictory. There is limited data about khat effect on blood glucosespecially in our setting. Therefore, this study aims to investigate this issue.
Objective: In this study, we compared FBS among khat chewer and khat chewer diabetic andhealthy subjects.
Method: A cross-sectional study include 200 confirmed diabetic and healthy subjects grouped into four groups (diabetic khat chewers n=50, diabetic non khat chewer n=50, healthy khat chewern=50 and healthy non-khat chewer n=50). FBS was determined by enzymatic method (GOD&GHK) using Biosystem A25 and COBAS 6000 chemistry analyzers at Hiwot Fana and St. Peterhospital clinical chemistry laboratory respectively. Non-parametric tests Mann-Whitney test (2independentsample test) and Kruskal-Wals test (K-independents sample test) were used tocompare fasting blood glucose among khat chewer and non-khat chewer with in the groups andbetween groups respectively. P<0.05 is taken to be statistically significant.
Result: - Of the total respondents 83(41.5%) and 117(58.5%) were male and female respectively.Without age and gender adjustment the overall Median±IQR FBS difference among khat chewersand non-khat chewers were (159.5±83) mg/dl and (202±79) mg/dl respectively in diabetic patientsusing GOD. Similarly, when we compare between healthy non-khat chewers and khat chewers,khat chewers have lower (Median±IQR) fasting blood glucose level (82±18) mg/dl than that of thenon-khat chewers (94±13) mg/dl when tested by GOD. Generally, there was significantly lowerblood glucose level measured by both GOD and GHK methods in both diabetics and healthygroups of khat chewers. There was also percentage difference of median FBS with in the samegroup when measured by GOD and GHK methods.
Conclusion and recommendation: -There was significant effect of khat on blood glucose levelamong khat chewer and non-khat chewer in diabetic and healthy individuals. Based on the presentstudy finding, further studies have to be conducted to identify khat constituent associated withhypoglycemic effect and further elucidate khat effect on systemic metabolism.
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Khat chewing, serum fasting glucose level