Epidemiology of Tuberculosis and the Diagnostic Performance of Lipoarabinomannan Assay for Tuberculosis Testing Among Patients with Chronic Kidney Disease and Diabetes Mellitus in Ethiopia

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dc.contributor.advisorMikias Negash
dc.contributor.advisorRahel Alemu
dc.contributor.authorBekalu Yirga
dc.date.accessioned2026-06-22T10:55:18Z
dc.date.available2026-06-22T10:55:18Z
dc.date.issued2025-06-07
dc.description.abstractBackground: Hematological Parameters Have Been Proposed as Useful Adjuncts in the Clinical Evaluation of Patients with Congestive Heart Failure (CHF), Offering Potential Insight in to Disease Severity When Interpreted Alongside Other Diagnostic Tools. Objectives: To Assess Selected Hematological Parameters in Adult Patients with CHF Across Different New York Heart Association (NYHA) Functional Classes. Methods: A Cross-Sectional Study Was Conducted Among 206 Adult Patients with CHF Attending the Cardiology Department at St. Paul's Hospital Millennium Medical College (SPHMMC), Addis Ababa, In February 2022. Peripheral Venous Blood Samples (5 Ml) Were Collected in EDTA Tubes and Analyzed Using the Dxh 800 Beckman Coulter Hematology Analyzer. Data Were Processed Using SPSS® Version 26.0. A P-Value Of < 0.05 Was Considered Statistically Significant. Result: Significant Differences in Hematocrit (Hct), Lymphocyte Count (Lymph), And Red Cell Distribution Width (RDW) Were Observed Between NYHA Functional Classes. Specifically, The Mean Values of Hct, Lymph, And RDW Differed Significantly Between NYHA Class II And Class IV (Hct: P = 0.035; 95% CI: −10.567 To −0.284; Lymph: P = 0.035; 95% CI: 0.027 To 1.096; RDW: P = 0.002; 95% CI: −2.926 To −0.489). Additionally, Comparisons Between NYHA Class I And Class III Revealed Significant Differences in Lymph (P = 0.010; 95% CI: 0.127 To 1.279) And RDW (P = 0.046; 95% CI: −2.796 To −0.016). Receiver Operating Characteristic (ROC) Curve Analysis Demonstrated That RDW Had an AUC Of 0.663 (95% CI: 0.549–0.777; P = 0.009) And Lymph Had an AUC Of 0.657 (95% CI: 0.543–0.771; P = 0.012) In Distinguishing NYHA Class I From Class III, With Cut-Off Values Of 13.5% For RDW And 1.718 × 10⁹/L For Lymph. When Comparing NYHA Class I And Class IV, RDW Showed an AUC Of 0.708 (95% CI: 0.608–0.808; P = 0.001) And Lymph an AUC Of 0.622 (95% CI: 0.514 0.729; P = 0.035), With Corresponding Cut-Off Values Of 15.9% And 1.95 × 10⁹/L, respectively. Conclusion: Significant Differences in Hematological Parameters, Including Hct, RDW, And Lymph, Were Observed Across NYHA Functional Classes, Particularly in Later Stages Of CHF. These Findings May Support Their Further Investigation as Potential Markers in the Clinical Assessment of Disease Progression.
dc.identifier.urihttps://etd.aau.edu.et/handle/123456789/8257
dc.language.isoen
dc.publisherAddis Ababa University
dc.subjectCongestive Heart Failure
dc.subjectHematological Parameters
dc.subjectNyha Classification
dc.subjectRed Cell Distribution Width
dc.subjectLymphocyte Count
dc.subjectHematocrit
dc.titleEpidemiology of Tuberculosis and the Diagnostic Performance of Lipoarabinomannan Assay for Tuberculosis Testing Among Patients with Chronic Kidney Disease and Diabetes Mellitus in Ethiopia
dc.typeThesis

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