Survival Status and Associated Factors of Death Among Cervical Cancer Patients Attending at Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia.
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Date
2019-06
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Addis Ababa University
Abstract
Background: Cervical cancer is a cancer of uterine cervix caused by mostly sexually-acquired infection called Human papillomavirus (HPV). Death of cervical cancer varied 18-fold betweendifferent regions of the world. In developing countries, less than 50% of women with cervical cancer survive longer than 5 years. Thirty-five point nine new cases of cervical cancer are
diagnosed and 22.6 die per 100,000 women annually in Ethiopia. Objective: The objective of this study was to asses survival status and associated factors of death among cervical cancer patients attending at Tikur Anbesa Specialized Hospital, Ethiopia,2019. Methods and materials: Institutional based retrospective cohort study was conducted from March to April 2019 at Tikur Anbesa Specialized Hospital oncology department (TASH). Data was collected from patient’s chart using pre-tested and structured checklist prepared in English. Differences in survival among different variables was compared using the log-rank test. Variables with pvalue<0.05 in multivariate analysis were considered as significantly associated to survivaltime.
Result: The overall survival rate was 38.62% at five years. It is found that there were asignificance differences in survival experience between categories of stage of cervical cancer,age of patients, comorbidity, substance use, base line anemia and treatment modalities. Being stage IV [AHR = 11.76; 95% CI (4.02-34.4)] ,being advanced age [AHR = 5.99; 95% CI (2.117.08)],being comorbid[AHR=1.58; 95%CI(1.14-2.19)], using substance[AHR=1.56;95%
CI(1.09-2.22)] and being anemic [AHR=1.6;95% CI(1.11-2.36)] increased the risk of death.
Conclusion: The five-year overall probability of survival rate among cervical cancer patient was 38.62.%, which is lower when compared with those of high- and middle-income countries.Significant factors of death after diagnosis of cervical cancer were; advanced FIGO stage, baseline anemia, comorbidity, substance use, advanced age and treatment modality.
Recommendations: Better to expand cervical cancer early screening programs and treatment facilities, give priority for comorbid and anemic patients, strengthen awareness in collaboration with public medias about cervical cancer prevention, screening and treatment options.
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Cervical cancer, survival status, Tikur Anbesa specialized hospital, Ethiopia