HIV seroconversion and associated factors among booked seronegative pregnant women in Kobo town and Raya Kobo woreds, North wollo,Ethiopia: institution based cross- sectional study.

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Addis Abeba University


Background: Under the current practice, pregnant women who were Human Immunodeficiency Virus (HIV) negative on the first test are considered to be HIV negative throughout. A repeat HIV test three months later would identify HIV seroconversion and ensure early intervention to prevent mother to child transmission of the virus. The objective of this study is therefore to measure the magnitude of HIV seroconversion and to identify factors associated with HIV seroconversion among booked first-time test seronegative pregnant women. Methods: An institution-based cross-sectional study was conducted among HIV negative pregnant women in Kobo Town and Raya Kobo Woreda, North Wollo, Ethiopia from June to July 2020. Data were collected using a questionnaire through face-to-face interviews along with a client card review. HIV re-testing was performed to know the current HIV status of pregnant women. The collected data were entered into Epi data version 4.4.1 and were exported and analyzed by SPSS version 25. A p-value < 0.25 in the bivariate analysis were entered in the multivariable logistic regression analysis and a p-value of < 0.05 was taken as statistically significant. Result: From a total of 494 pregnant women who were screened and reported negative for HIV at first ANC, six (1.2%) were HIV seropositive during retesting. Upon multivariable logistic regression, pregnant women who have had a reported history of sexually transmitted infections [AOR=7.98; 95% CI (1.206, 52.818)], participants’ partners reported travel history for work frequently [AOR=6.00; 95% CI (1.093, 32.993)], and sexually abused pregnant women [AOR=7.82; 95% CI (1.194, 51.243)] were significantly associated with HIV seroconversion. Conclusion: The notable seroconversion rate found in this study implies that it is not enough to test pregnant mothers once during the first antenatal care clinic. Rescreening of pregnant women after the booking is a beneficial strategy to allow the timely provision of ART prophylaxis to HIV seroconverting women and their exposed babies for the elimination of mother to child transmission of HIV. Further expanded and large scale study should be conducted to understand the magnitude and the factors of HIV seroconversion during pregnancy at various levels.



Human Immunodeficiency Virus, Pregnancy, Seroconversion, Booking, Kobo, Vertical transmission.