Hospital acquired infections, antimicrobial drug resistance patterns and associated risk factors among under five children attending Yekatit 12 Hospital Medical College, Addis Ababa Ethiopia.
| dc.contributor.advisor | Desta, Kassu (MSc, PhD candidate) | |
| dc.contributor.author | Woldesenbet, Zerihun | |
| dc.date.accessioned | 2018-12-05T12:19:11Z | |
| dc.date.accessioned | 2023-11-06T08:56:23Z | |
| dc.date.available | 2018-12-05T12:19:11Z | |
| dc.date.available | 2023-11-06T08:56:23Z | |
| dc.date.issued | 2018-06 | |
| dc.description.abstract | Hospital acquired infection (HAI) is an infection which develops 48 hours after hospital admission, that was not incubating at the time of admission to hospital. In patients with HAI, costs as well as the use of antibiotics increase with an extended hospitalization. There is limited information on the magnitude of HAI in Ethiopia particularly in pediatrics patient groups. Objective: The aim of this study is to assess the incidence of hospital acquired infections, antimicrobial drug resistance patterns and associated risk factors among under five children attending Yekatit 12 Hospital Medical College, Addis Ababa Ethiopia. Methods: This was a prospective cohort study that was conducted at City –Government of Addis Ababa, Yekatit 12 Hospital Medical College from January to April 2018. All admitted patients who did not have antibiotic and stay at least 48 hours during sample collection period were included with the outcome variable being the prevalence of hospital acquired infection. Blood, urine, body fluids, stool, and swabs were cultured on corresponding media(brain heart infusion, chocolate agar, blood agar, MacConkey…etc) for isolation and identification of the bacteria and Kirby- Bauer method for antibiotic susceptibility testing. Data were analyzed using SPSS version 23. Chi-square tests were performed to determine risk factors associated with HAI. Results: A tA tA total of 720 under five children were admitted during the study period (from January 2018 to April 2018 ). Out of this 435 children fulfilled the study criteria and were included in the study. Of the 435 children, 255(58.7%) were males and 180(41.3%) females and resulting in male to female ratio of 1.41:1. About 259 were neonates and the remaining 176 were children age between 21days and 5 years. The overall incidence of hospital acquired infections in this study was 8.5% with the most common isolate being Klebsiella pneumonia (n = 19) followed by S. aureus (n=7). Klebsiella pneumoniae has shown high level of resistance (100%) to most of third generation cephalosporins and S. aureus has shown high resistance to penicillin and cotrimoxazole. Prevalence of MDR seen among K. pneumonia which is 100%, followed by Acinetobactor species in this case we have 66.7% MDR. The presumed predisposing factors were not found statistically associated. Conclusion: This study showed that hospital acquired infections remains high especially in neonatal intensive care unit complicating disease of already prone children. Therefore, appropriate infection prevention has to be strengthened. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/14902 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Hospital acquired infection, multiple drug resistance and under five children | en_US |
| dc.title | Hospital acquired infections, antimicrobial drug resistance patterns and associated risk factors among under five children attending Yekatit 12 Hospital Medical College, Addis Ababa Ethiopia. | en_US |
| dc.type | Thesis | en_US |