Antihyperglycemic and antihyperlipidemic effect of Persea americana mill fruit juice in high fat diet and low dose streptozotocin (STZ) induced type 2 diabetic male albino Wistar rats
| dc.contributor.advisor | Genet, Solomon (PhD) | |
| dc.contributor.advisor | Tufa, Abdisa (PhD fellow) | |
| dc.contributor.author | Girma, Ture | |
| dc.date.accessioned | 2020-07-08T08:00:15Z | |
| dc.date.accessioned | 2023-11-29T04:18:23Z | |
| dc.date.available | 2020-07-08T08:00:15Z | |
| dc.date.available | 2023-11-29T04:18:23Z | |
| dc.date.issued | 2020-06 | |
| dc.description.abstract | Introduction:Type II diabetes is an alarming rate problem globally and in Ethiopia due to change in diatery habits and sedentary life style. Serious complications are associated with diabetes, particularly macrovascular and microvascular complications. Early controlling blood glucose significantly reduces the risk of complications of diabetes, but yet no effective cure for it, even though available drugs currently used in managing the disease are associated with several undesirable side effects. Traditional treatment with low cost and minimum side effect is used to treat diabetes across the world due to the different types of ingredients present in medicinal plants that act on a variety of targets by various modes and mechanisms. Ethiopia is rich in traditional medicinal plants and Persea americana mill is also part of this which people comsume as food. Objectives: In this study the effect of Persea americana mill fruit juice on FBG, weight, LDL-c, TG, TC, HDL-c and total protein in HFD/ low dose STZ indued type II diabetes mellitus has been evaluated in male albino wistar rats. Materials and Methods: Thirty six male albino wistar rats of 150-200 g weight were divided in to six different groups. Except six rats, the rest thirty fed on HFD for one month to induce prediabetes and insulin resistance, next followed by 35mg/Kg of STZ injection. Group I served as normal control; Group II served as diabetic control; Group III recieved 7mg/Kg of metformin; Group IV, V and VI were given 856 mg/kg, 1712 mg/kg and 2568 mg/kg of Persea americana mill fruit pulp juice for six weeks respectivily. The effect of fruit pulp juice on food intake and weight was measured by triple beam balance. After forty-five days treatment, the rats were fasted overnight (12 to 14 hours), anaesthetized and blood sample was collected by cardiac puncture for biochemical tests. Results were analyzed using one way ANOVA at a 5% level of significance. Results: In higher dose (2568 mg/Kg) of Persea americana mill fruit pulp treated group food consumption,weight, FBG, LDL-c were signifacantly reduced and HDL-c increased (P<0.005) compared to diabetic control. Middle dose (1712mg/Kg) treated group showed a decrease in FBG on 6 th week and improve HDL-c. Treatement of rats with Persea americana fruit juice change TG ,total protien and creatinine but not significant. Oral antidiabetes drug metformin showed significant reduction on pellet consumption, weight, FBG and lipid profile. Conclusion:These results indicated that Persea americana mill fruit juice has antihyperglycemic and antilipidemic effect possibly through reduction of fasting blood glucose, LDL-C and increasing HDL-C, in T2D induced rats. . | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/21899 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | T2DM, Persea americana mill, HFD, STZ, hyperglycemea, dyslipidemea | en_US |
| dc.title | Antihyperglycemic and antihyperlipidemic effect of Persea americana mill fruit juice in high fat diet and low dose streptozotocin (STZ) induced type 2 diabetic male albino Wistar rats | en_US |
| dc.type | Thesis | en_US |