Outcome of patients with Acute Coronary Syndrome admitted to Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
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Date
2017-01
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Addis Ababa University
Abstract
Outcome of patients with Acute Coronary Syndrome admitted to Tikur Anbessa
Specialized Hospital, Addis Ababa, Ethiopia
Kassahun Bogale
Addis Ababa University, 2017
Worldwide, coronary artery disease (CAD) is the single most frequent cause of death. Over
seven million people every year die from CAD, accounting for 12.8% of all deaths. The
objective of this study was to assess the treatment outcome and associated factors for Acute
Coronary Syndrome (ACS) patients admitted at Tikur Anbessa Specialized Hospital (TASH). A
retrospective cross sectional study was conducted by chart review of patients who were
discharged with a diagnosis of ACS during the period January 1, 2012 to December 31, 2014. Of
124 ACS patients who were admitted during the three years period, 90(72.6%) were diagnosed
as STEMI. The mean age was 56.3 ±13.7 years. The average length of hospital stay was 9.77±
6.42 days. The average time from onset of ACS symptoms to presentation in the emergency
department was 3.8 days (91.7 hours). In about 76 (61.3%) patients hypertension was the leading
risk factor for development of ACS. 36.4% of ACS patients in TASH were either Killip class III
or IV. Biomarkers were measured for 118(95.2%) patients. 79.2% of patients had ejection
fraction (EF) of less than 40% and 29.2% had less than 30%. In-hospital medications include
loading dose of aspirin (79%), anti-coagulants (77.4%), beta-blockers (88.1%), statins (85.5%),
morphine (12.9%), and nitrates (35.5%). The in-hospital mortality was 27.4%. Predictors of inhospital
mortality in TASH included age (P=0.042), time from symptom onset to presentation
(P=0.001), previous history of hypertension (P=0.025), being Killip class III and IV (P=0.001),
and STEMI diagnosis (P=0.005). Hence, based on the results the medical management of ACS
patients in TASH was in line with the recommendations of international guidelines but inhospital
mortality was very high (27.4%).
Key words: Acute Coronary Syndrome, Outcome, In-Hospital Mortality
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Keywords
Acute Coronary Syndrome, Outcome, In-Hospital Mortality