Antibacterial Activity of Moringa Stenopetala against Some Human Pathogenic Bacterial Strains
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Date
2012-06
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Addis Ababa University
Abstract
An emerging of antibiotic resistance brings most serious public health problems. It
is therefore, important to look for more effective, safer and less toxic alternate options of
treatment. The aim of the present study was to investigate antibacterial activity of Moringa
stenopetala against some human pathogenic bacteria using disk diffusion method and agar
dilution for minimum inhibitory concentration. The result revealed that, most of the plant
extracts had antibacterial activity. Staphylococcus aureus was found to be the most susceptible
bacteria to crude 80% methanol extract of seeds and ethyl acetate extract of root barks with
inhibition zones of 18.66±0.88mm and 16.00±1.15mm and minimum inhibitory concentration of
1.25mg/ml and 2.5mg/ml respectively, whereas Pseudomonas aeruginosa was the most resistant
bacteria to all of crude extracts. Similarly, Staphylococcus aureus was the most susceptible
bacterial strain to chloroform fraction with inhibition diameter of 28.00±0.57mm and minimum
inhibitory concentration of 0.31mg/ml, while Pseudomonas aeruginosa was the most resistant
strain with inhibition zone of 9.66±0.33mm and minimum inhibitory concentration of10mg/ml
respectively. In conclusion, this study is not only proves antibacterial activity of Moringa
stenopetala, also provides a scientific basis for their traditional use. Pure chemical compounds
and antimicrobial activity against many fungi and bacteria should be studied to use them as
sources and templates for synthesis of drugs to control infectious diseases.
Key words and phrases: Antibacterial activity, Moringa stenopetala, traditional medicine,
extracts, fractionation, MIC, solvents
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Keywords
Antibacterial activity, Moringa stenopetala, traditional medicine, extracts, fractionation, MIC, solvents