A comparison of the effect of intravenous Dexamethasone and Pethidine for prevention of post spinal Anesthesia shivering in patients who underwent transurethral resection of the prostate.

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Addis Abeba University


Background: Shivering is commonly observed as a complication after Regional Ansthesia; even it is more common for urologic operations and causes several complications that have serious physiologic effects. Pethidine have been thought as a standard for prevention and treatment of shivering but it is not without side effects. Studies showed that dexamethasone also has promising effect with fewer side effects even though there is controversies about its comparable effect with the standard antishivering drug that of pethidine. Objective: The main objective of this study was to compare the effect of prophylactic dexamethasone and pethidine on prevention of post spinal anesthesia shivering for patients who underwent transurethral resection of the prostate (TURP) . Methods: An institutional based prospective cohort study was conducted on 64 patients who fulfilled inclusion criteria and underwent transurethral resection of the prostate. Convenient sampling technique was used to recruit study participants and data was collected by pretested structured questioner. The data was entered in SPSS version 20 for analysis of variable, independent sample t-test statistics and Mann-Whitney U test were used for quantitative data that was distributed normally and non normally respectively. Chi square test was used to compare difference in categorical data. P -value <0.05 was considered as statistically significance. Result: The incidence and severity of shivering was comparable between pethidine and dexamethasone group (p value>0.05).There was no statistically significance difference in mean time to first onset of shivering between dexamethasone (65minute) and pethidine (81minute) group (p=0.23).The median consumption of total antishivering medication was comparable between dexamethasone (54.2mg of tramadol) and pethidine (68.8mg of tramadol) group (p=0.21). Conclusion and Recommendation: we conclude that dexamethasone (4mg) is equally effective as pethidine (25mg) that of standard antishivering drug and we recommend the use of dexamethasone (4mg) as an alternative of pethidine as a prophylaxis for prevention of shivering for patients undergoing TURP procedures under spinal ansthesia.



Dexamethasone,Pethidine,Spinal Anesthesia , patients , transurethral resection, prostate.