A comparison of the effect of intravenous Dexamethasone and Pethidine for prevention of post spinal Anesthesia shivering in patients who underwent transurethral resection of the prostate.
No Thumbnail Available
Date
2020-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background: Shivering is commonly observed as a complication after Regional Ansthesia;
even it is more common for urologic operations and causes several complications that have
serious physiologic effects. Pethidine have been thought as a standard for prevention and
treatment of shivering but it is not without side effects. Studies showed that dexamethasone
also has promising effect with fewer side effects even though there is controversies about its
comparable effect with the standard antishivering drug that of pethidine.
Objective: The main objective of this study was to compare the effect of prophylactic
dexamethasone and pethidine on prevention of post spinal anesthesia shivering for patients
who underwent transurethral resection of the prostate (TURP) .
Methods: An institutional based prospective cohort study was conducted on 64 patients who
fulfilled inclusion criteria and underwent transurethral resection of the prostate. Convenient
sampling technique was used to recruit study participants and data was collected by pretested
structured
questioner.
The
data
was
entered
in
SPSS
version 20 for analysis
of
variable,
independent
sample
t-test
statistics
and
Mann-Whitney
U
test
were
used
for
quantitative
data
that
was distributed normally and non normally respectively. Chi square test was used to
compare difference in categorical data. P -value <0.05 was considered as statistically
significance.
Result: The incidence and severity of shivering was comparable between pethidine and
dexamethasone group (p value>0.05).There was no statistically significance difference in
mean time to first onset of shivering between dexamethasone (65minute) and pethidine
(81minute) group (p=0.23).The median consumption of total antishivering medication was
comparable between dexamethasone (54.2mg of tramadol) and pethidine (68.8mg of
tramadol) group (p=0.21).
Conclusion and Recommendation: we conclude that dexamethasone (4mg) is equally
effective as pethidine (25mg) that of standard antishivering drug and we recommend the use
of dexamethasone (4mg) as an alternative of pethidine as a prophylaxis for prevention of
shivering for patients undergoing TURP procedures under spinal ansthesia.
Description
Keywords
Dexamethasone,Pethidine,Spinal Anesthesia , patients , transurethral resection, prostate.