Thyroid and Selected Metabolic Panel among Multi- Drug Resistant Tuberculosis Patients Attending Saint Peter Specialized Hospital, Addis Ababa, Ethiopia
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Date
2021-03
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Addis Abeba University
Abstract
Background: One of the challenges in multidrug resistance tuberculosis (MDR-TB)treatment is the side effect of drug reactions associated with its medications. Among thishypothyroidism and lipid profile are the adverse drug reactions (ADR) challenging in MDRTBtreatment. However, there is limited evidence on the level of hypothyroidism and lipidprofile abnormalities and the risk factors associated with them among MDR TB patients inEthiopia.
Objective: To determine thyroid profiles and associated factors among MDR-TB patientson treatment in Saint Peter‟s Specialized Hospital Addis Ababa, Ethiopia.
Methods and Materials: A cross-sectional study was conducted amongpatients on MDRTBtreatment at Saint Peter‟s Specialized Hospital in Addis Ababa, Ethiopia from January2020 to November 2020. Consecutive sampling method was used to enroll a total of 162participants. From each participant, after getting informed consent and interview onsociodemographicand anthropometric data, Five ml blood sample was collected in serumseparated tubes (SST) and analyzed by Cobas Integra chemistry analyzer. Data were enteredinto Microsoft Excel window 2010, and analyzed by SPSS software version 23.Descriptive statistics were used to summarize socio-demographic and clinical characteristics of the participants. Logistic regression model was used to determine factors associated withhypothyroidism and lipid profile abnormality. P-values<0.05 were considered as statisticallysignificant in all the analyses.
Results: Of 162 patients 99 (61.1%) were males. Mean age of the study participant was 35.9± 13.6 years. Of the total patients 26 (16%) were diabetic, and the prevalence ofhypothyroidism was 32 (19.8%).The most frequently occurring lipid profile abnormalitieswere HDL-C and TG with 106(65.4%) and 23 (14.2%) respectively. On the other hand,among the study participants, the fasting blood sugar value was hypoglycemic andhyperglycemic in 24 (14.8% and 42 (25.9%) cases, respectively. The presence of comorbidity(p = 0.006), Being underweight (p = 0.050) and Prothionamide drug use (p <0.001) were significantly associated with hypothyroidism.
Conclusion: The proportion of hypothyroidism in MDR-TB patients was considerable.Presence of co-morbidity, being underweight and Prothionamide use were factorssignificantly associated with hypothyroidism. Lipid profile abnormalities also occurredamong MDR-TB patients. Regular monitoring of thyroid function test and lipid profile inMDR-TB patients is required. Conducting large scale prospective cohort study is necessaryto determine the risk factors associated with hypothyroidism and lipid profile abnormalitiesdue to MDR-TB drugs.
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Keywords
Tuberculosis, Drug resistant, Thyroid hormone, lipid profile