Clinical characteristics and Endoscopic outcomes of patients who underwent UGIE for an indication of dyspepsia at Tikur Anbesa Hospital Gastroenterology referral clinic from December 1, 2015- December 30 2019.
No Thumbnail Available
Date
2020-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background:
Dyspepsia is a frequent syndrome in our country, where there is limited endoscopy service and
high prevalence of Helicobacter pylori (H. pylori) infection with some having an organic cause
while others have functional dyspepsia. Endoscopy is the most accurate method of diagnosis of
most endoscopically positive conditions associated with dyspepsia, including gastric cancer, peptic
ulcer disease, esophagitis and gastro- duodenitis. Helicobacter pylori infection is associated with
various upper gastrointestinal pathologies.
Objective: The purpose of this study is to Clinical characteristics and Endoscopic outcomes of
patients who underwent UGIE for an indication of dyspepsia at Tikur Anbesa Hospital
Gastroenterology referral clinic.
Methods: A Hospital based- Retrospective cross-sectional study was conducted using pretested,
structured questionnaires to determine clinical characteristics of patients between 17-76 years’ old
who underwent endoscopic procedure at Tikur Anbesa Hospital Gastrointestinal referral clinic.
The study is conducted from April 2020-september 2020 G.C. A sample of 270 patients were
included in the study. Based on the structured questionnaire, presenting symptom, alarm symptom,
H.pylori test result and endoscopic finding and risk factors are assessed by the investigator.
Organic dyspepsia findings were analyzed with different variables to verify statistically significant
associations.
Result:
Two hundred seventy patients were included and analyzed in the study. The mean age was 38 years
and Men comprised 58.5% of the study. 37 % of the patients reported alarm symptoms. The
prevalence of H. pylori infection was 37.8 %. Endoscopic finding constitutes Normal, 29%, Ulcer
disease, 16% (duodenal in 13% and gastric ulcer in 3%), Gastropathy/Gastritis 33 %, 13% had
GERD and esophageal erosion and gastric mass account for 2.2 %. Ulcer diseases were found to
have statistically significant association with H. pylori infection OR, (0.38 95% CI, (0.143-0.552)
and alarm symptom (iron deficiency anemia and persistent vomiting), p <0.05.
Conclusion:
The endoscopic diagnosis in our setting showed predominance of abnormal findings and of this
ulcer disease is the major endoscopic outcome with strong associations with Helicobacter pylori
infection and GERD diagnosis was also shown to be frequent endoscopic diagnosis among our
dyspeptic patient. Whereas cancer was an uncommon finding, despite the high prevalence of H.
pylori.
Description
Keywords
Endoscopy, dyspepsia, clinical characteristics