Establishment of Reference intervals for common hematology test parameters from apparently healthy geriatrics in Asella town, southeast Ethiopia
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Date
2020-06
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Addis Abeba University
Abstract
Background: Reference intervals are an important tool to identify abnormal laboratory
test results. Hematology reference values are useful to interpret hematology results and
make clinical decisions, but these values have not been established for geriatrics in Asella
town.
Objective: To establish reference intervals for common hematology test parameters from
apparently healthy geriatrics in Asella town, southeast Ethiopia from January to April
2020.
Methods: A community-based cross-sectional study was conducted from January to
April 2020. Interviewer administered questionnaire was used to collect data of sociodemography
and other characteristics from 342 eligible geriatrics. Weight, height, blood
pressure, MUAC and temperature were measured and 8 milliliter blood sample was
collected. Screening tests like HIV, HBsAg, HCV, syphilis, concentration method and
wet mount of stool examination and urinalysis were performed. Hematological parameter
was measured by Sysmex kx-21 hematology Analyzer. The data were analyzed by SPSS
version 21. The non-parametric independent Mann–Whitney U test were used to compare
the parameters between two gender groups.
Result: The reference intervals of red blood cell, white blood cell, platelet count,
hemoglobin (HGB), and hematocrit (HCT) in male Geriatrics were 3.8–5.85 × 10
/L,
3.1–9.66 × 10
9
/L, 115.8–353 × 10
9
/L, 12.4-17.76g/dL and 35.06-50.2%.The respective
values for females were 3.94-5.48×10
12
/L, 3.13-8.4× 10
9
/L, 137.5-406× 10
/L, 12.516.4g/dL,
and 36.09-48.2%.By comparing the two genders by non parametric Mann–
Whitney U test, most of the hematological parameters showed significant differences
among two genders (p-value <0.05).
Conclusion: The reference intervals which were established by this study was different
from the existing reference values as well as from other african countries and caucasion
population. This difference could be due to difference in dietary pattern, ethnic difference
as well as in the methodological used.
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Keywords
Reference interval, hematological parameters, geriatrics, southeast, Ethiopia.