Prevalence of Drug Resistance of Mycobacterium Tuberculosis in Harar (Eastern Ethiopia)

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Addis Abeba University


A hospital based cross sectional study was carried out in order to describe the magnitude of antituberculosis drug resistance and identify the risk factors associated with it. The study was carried out in Harar tuberculosis centre which is the major tuberculosis treatment centre in eastern Ethiopia. A total of 338 smear/culture positive patients were enrolled in the study between October 10, 1994 and January 20, 1995. Exposure status was determined through interview; drug resistance and HIV status were determined through laboratory investigation. The overall prevalence of resistance to one or more anti-tuberculosis drugs was 126/338 (37.3%). Initial resistance was 82/252 (32.5%) while that of acquired was 44/86 (51 . 2%). History of previous treatment was the strongest predictor of anti-tuberculosis drug resistance (p <0 . 005). HIV infection was found to be an important predisposing factor in those who had history of previous treatment (p< 0.05). The prevalence of drug resistance is high in Harar. There is a need for periodic national drug resistance survey. Implementation of the WHO recommended supervised treatment with multi-sectoral approach is suggested



Prevalence of Drug Resistance