Clinical characteristics and outcomes of patients with dialysis requiring AKI at the Tikur Anbessa specialized hospital.
| dc.contributor.advisor | Dr.Melike, Addissu(Consultat internist and Nephrologist) | |
| dc.contributor.author | Getachew, Nebiyu | |
| dc.date.accessioned | 2021-01-26T06:38:58Z | |
| dc.date.accessioned | 2023-11-05T09:37:04Z | |
| dc.date.available | 2021-01-26T06:38:58Z | |
| dc.date.available | 2023-11-05T09:37:04Z | |
| dc.date.issued | 2019-11 | |
| dc.description.abstract | Background: Acute kidney injury (AKI) in developing countries is the disease of the young and children while developed countries elderly patients with co morbid conditions predominate. The management of patients with acute kidney injury (AKI) is supportive, with renal replacement therapy (RRT) indicated in patients with severe kidney injury. Even though, government run dialysis service is given in few centers in Ethiopia, data on epidemiological and clinical characteristics of dialysis requiring AKI patients and its outcome is sparse. Objectives: The objective of this study is to describe socio-demographic, clinical characteristics of patients with dialysis requiring AKI and their renal and hospital outcome at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods: The study is an institution based retrospective chart review of patients with AKI who were hospitalized and had hemodialysis inTikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia from July 14, 2016 to September 2019. Data on socio-demographic characteristics, clinical profiles, and dialysis and hospital outcomes were collected using a structured questionnaire. Data entry and analysis was done on (SPSS) version 20. Frequency tables and odds ratio was used to explain and analyze the results. Factors found to be significantly associated with mortality on bivariate analysis (P-value< 0.05) were analyzed with a multivariate model using logistic regression to determine the predictors of in-hospital mortality. P values less than 0.05 were considered statistically significant. Result A total 275 patients underwent hemodialyis during the period, of which 130 patients, 71 females (54.6%) and 59 males(45.6%), with a median age of 34 were included in the study. The most common causes of AKI were sepsis (33.8%), glomerulonephritis(31.5%) and pregnancy related causes (16.2%). A quarter of the patients (25.4%) did require ICU admission. The in hospital mortality was 26.2%. Sepsis, co morbid heart failure and age above 50 year were associated with increased mortality. In 12(9.2%) patients’ glomerulonephritis as a cause of AKI increased the risk of dialysis requirement beyond 4 weeks. Conclusion In this setting the majority of patients with dialysis requiring AKI are young. We have observed a shift in the etiology of dialysis requiring AKI in the last two decades; from Malaria and septic abortion predominated to sepsis and glomerulonephritis. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/24830 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Acute kidney injury, dialysis requiring AKI, AKI-D, Ethiopia | en_US |
| dc.title | Clinical characteristics and outcomes of patients with dialysis requiring AKI at the Tikur Anbessa specialized hospital. | en_US |
| dc.type | Thesis | en_US |