Insulin Resistance and Dyslipidemia in Type 2Diabetic Patients: A Cross-Sectional Study at the Diabetic Clinic of Tikur Anbessa Specialized Teaching Hospital
No Thumbnail Available
Date
2015-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
Background: Type 2 diabetes is a major non-communicable disease with an increasing
prevalence in Ethiopia and worldwide. About 2% of Ethiopians are reported to have type 2
diabetes, but this may be an underestimate, due to a paucity of studies on diabetes epidemiology
in Ethiopia.
Objective: Assessment of insulin resistance and dyslipidemia in type 2 diabetic patients
attending diabetic clinic of the Tikur Anbessa Hospital, Addis Ababa.
Methods: This study was carried out on 106 type 2 diabetic patients attending Tikur Anbessa
Specialized Hospital Diabetic Clinic. Fasting blood glucose, serum lipid panels, serum insulin
concentrations, Apo lipoprotein A-1 and Apo lipoprotein B were measured in diabetics who were
taking oral medications. Patients taking insulin were excluded from the study. Insulin resistance
was measured by calculating HOMA-IR for each patient. Blood pressure, body mass index
(BMI), waist circumference and smoking status were also determined.
Result: Most patients (80%) had poorly controlled fasting blood glucose (>126 mg/dL), and
this was similar for males and females. Serum triglycerides were abnormally high in 58.7% of
patients, LDL-cholesterol levels were elevated above 100 mg/dL in 50% of patients, and serum
HDL-c levels were abnormally low in 76.9 % of patients.88.6% of the diabetic patients had
showed significant insulin resistance (P<0.05), indicated by an elevated HOMA-IR index (>3.0).
Two third of the diabetic patients showed normal blood pressure. Furthermore, sixteen of
the 106 patients were cigarette smokers and smokers over 40 years old with diabetes had
substantial cardiovascular risks as determined by their Framingham cardiovascular risk score.
Conclusion: These results emphasize the need for improvedprograms for diabetes screening,
prevention and care in Ethiopia. The biochemical and medical significance of the results are
discussed.
Key words:Type2Diabetes,Insulin Resistance, Dyslipidemia, HOMA-IR, Apolipoprotine
Description
Keywords
Type2Diabetes,Insulin Resistance, Dyslipidemia, HOMA-IR, Apolipoprotine