Synthesis, In vitro Antimicrobial and in silico Studies of Aminoalkyl Derivatives of Carvacrol

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dc.contributor.advisorDaniel Bisrat
dc.contributor.authorAsaminew Goa
dc.date.accessioned2026-06-22T15:53:44Z
dc.date.available2026-06-22T15:53:44Z
dc.date.issued2025-05-13
dc.description.abstractThe global rise of antimicrobial resistance has created an urgent need for the development of new antimicrobial agents. Carvacrol, a natural phenolic compound, has drawn significant attention in medicinal chemistry due to its broad-spectrum biological activities. In the present study, two novel aminoalkyl derivatives of carvacrol were successfully synthesized through a Mannich-type reaction, which involves the condensation of carvacrol with formaldehyde and a secondary amine (dimethylamine or piperdine). Structural confirmation of the synthesized derivatives was carried out using spectroscopic techniques (1H-NMR and 13C-NMR). Based on the spectral data, the compounds were identified as 4-((dimethylamino)methyl)-5-isopropyl-2-
dc.identifier.urihttps://etd.aau.edu.et/handle/123456789/8451
dc.language.isoen_US
dc.publisherAddis Ababa University
dc.subjectCarvacrol
dc.subjectAminoalkyl
dc.subjectAntimicrobial
dc.subjectAntimicrobial Resistance (AMR)
dc.subjectAntibacterial
dc.subjectAntifungal
dc.subjectIn Silico study
dc.titleSynthesis, In vitro Antimicrobial and in silico Studies of Aminoalkyl Derivatives of Carvacrol
dc.typeImage, 3-D

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