Assessment of Health-Related Quality of Life in Patients with Inflammatory Bowel Disease at Tikur Anbessa Specialized Hospital, Ethiopia
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Date
2024-02
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Addis Ababa University
Abstract
Introduction: Inflammatory bowel diseases are chronic progressive/relapsing conditions that
affect the younger population and have been associated with reduced health-related quality of life.
HRQOL is an important outcome measure in IBD and helps to understand impact of the disease
on the patient and the effect of treatment on the disease.
Aim: To assess health-related quality of life in IBD patients and associated socio-demographic
and clinical factors.
Methods: A hospital-based cross-sectional study using the "Short Inflammatory Bowel Disease
Questionnaire" (SIBDQ) was conducted in Tikur Anbessa Special Hospital from September 1,
2023 to December 30, 2023. Data were entered and analyzed using SPSS version 27. Descriptive
statistics were used to show frequencies and percentages. A binary logistic regression model was
used to assess predictors of impaired HRQOL in patients with IBD. Strength of association is
measured by AOR and 95% CI. Variables with a P-value < 0.05 have a statistically significant
association.
Results: Thirty-one percent of IBD patients in our study had impaired HRQOL (SIBDQ<50) with
no statistically significant difference between IBD types, gender, marital status, residence, surgical
treatment and duration of IBD. Unemployment (AOR= 4.36; CI 95%:1.34-14.18; p=0.014), not
being in remission (AOR= 14.62; CI 95%: 2.31-92.53; p= 0.004), comorbidity (AOR= 9.18 ;CI
95%: 2.24-37.69, p=0.002), admission (AOR= 5.08; CI 95%: 1.45-17.76, p=0.011) and symptom
duration > 6 months before diagnosis (AOR= 4.679; CI 95%: 1.31-16.74; P=0.018) were
significantly associated with impaired HRQOL.
Conclusion: In our study, about one in three of IBD patients had impaired HRQOL. HRQOL was
better with controlled disease activity; no hospitalization, no EIMs, and no comorbidity; early
diagnosis, employment, and higher educational level.
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Keywords
IBD, QoL, HRQOL, health related quality of life, quality of life, inflammatory bowel disease, CD, Crohn’s disease, Ulcerative Clitis