Determination of Hematological Reference Interval for Apparently Healthy Children in Addis Ababa, Ethiopia
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Date
2021-05
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background: Clinical laboratory reference intervals are an important tool to identify abnormal
laboratory test results. The generating of hematological parameters reference intervals for local
population is very crucial to improve quality of health care, which otherwise may lead to
unnecessary expenditure or denying care for the needy. There are no well-established reference
intervals for hematological parameters in Addis Ababa, Ethiopia.
Objective: To determine for apparently healthy children hematological reference Interval for
apparently healthy children in Addis Ababa, Ethiopia.
Methods: A community based cross-sectional study design was employed involving 272
individual in Addis Ababa Ethiopia from April–October 2019. Blood samples of 10 ml was
collected in EDTA tubes using multi sample needle. A complete blood count (CBC) was
performed using Sysmex automated hematology analyzer. The data was analyzed by SPSS
version 26 statistical software and a non-parametric test used to generate reference intervals
based on the 2.5th and 97.5th percentiles of the data based on CLSI guideline.
Result: The reference interval of RBC count, WBC count, HB and PLT count were 4.235.59x10
12
/L, 2.95-10.89x10
9
/L, 12.02-16.04/dl and 208.90-538.9x10
9
/L, respectively for the age
category ( 5-11) while 4.43-5.85x10
12
/L, 3.05-9.43x10
9
/L,13.2-16.94g/dl, ,202.01-459.92x10
/L
for age group (12-14) respectively. Most of hematological parameters showed significant
differences such as RBC, HGB, HCT and MCV. No significant age-specific differences were
observed for MCH or MCHC, WBC and Platelet parameters.
Conclusion: This study provided population-specific hematological reference interval for
children in Addis Ababa, Ethiopian.
Description
Keywords
Reference interval, hematological parameter, children, Addis Ababa Ethiopia