Prevalence and risk factors of thyroid dysfunction among HAART taking patients at Bethel Teaching General Hospital Addis Ababa, Ethiopia
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Date
2018-06
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Addis Ababa Universty
Abstract
Background: Abnormal thyroid function test results are one of the common complications among HIV infected patients. Although the prevalence of overt thyroid disease does not appear to be significantly increased in HIV-infected patients, compared with the general population, specific patterns of abnormal thyroid function test findings are more frequently identified among HIV-infected patients.
Objective: To assess thyroid dysfunction rate and associated factors among HAART taking pa-tients
Methods: A hospital based cross sectional study was conducted from December 2017 to May 2018 at Bethel Teaching General Hospital, Addis Ababa, Ethiopia. A total of 300 HIV patients were enrolled in the study. Participants’ socio-demographic and clinical information was collected from hospital cards. Serum and EDTA whole blood was examined for Thyroid function tests and CD4+ T cell count levels, respectively. Descriptive statistics was used to express the socio demographic characteristics. Binary and multiple logistic regressions were computed to assess association be-tween variables using SPSS version 20. Odds ratio with confidence interval and P<0.05 have been be used to determine strength and statistically significant differences.
Results: Of the 300 individuals, 70 (23.3%) were identified with abnormal thyroid function, of whom, 47 (15.7%) were female and 23 (7.7%) male. 14(4.7%) were diagnosed with hyperthyroid-ism and 56(18.7%) with hypothyroidism. Of these, 35(62.5%) had subclinical hypothyroidism, 21 (37.5 %) had overt hypothyroidism. Out of these subclinical hypothyroid 23 (65.7%) were female and 12 (34.3 %) were males. The thyroid hormone levels however, did not correlate with duration of HAART and HIV duration. The levels of TSH, T3, T4 230(76.7%), 235(78.3%), 272(90.7%) for the majority of the participants were in the normal label respectively. There was a slight nega-tive correlation of CD4 counts with serum TSH levels (r =-0.1224 with p < 0.034)
Conclusion: High rate of thyroid function test abnormalities was observed in HAART receiving HIV/AIDS individuals. Subclinical hypothyroidism was the most common disorder and females were more exposed, warranting thyroid function tests monitoring.
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HIV, HAART, TFT, Thyroid Dysfunction, CD4+ T cell