Magnitude and Drug Resistance Patterns of Neisseria Gonorrhoeae among Sexually Transmitted Infection Treated Patients in Selected Health Centers of Addis Ababa , Ethiopia.
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Date
2018-04
Authors
Tadege Senait
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Publisher
Addis Ababa Universty
Abstract
Background: Gonococcus is a major public health challenge currently, due to the high frequencyof infections accompanied by a declining of treatment options. N.gonorrhoeae has repeatedly demonstrated its extraordinary capacity to develop resistance to all antimicrobials introduced for treatment of gonorrhea.
Objective: To determine magnitude and drug resistant patterns of Neisseria gonorrhoeae amoungSTI treated patients in health centers of Addis Ababa , Ethiopia
Methods: A prospective cross-sectional study was done from March-October 2017 at six publichealth centers of Addis Ababa, Ethiopia. Urethral and Cervical swabs were transported to EPHImicrobiology laboratory. Standard microbiological procedures were followed for isolating andidentification of N. gonorrhoeae. Antimicrobial sensitivity test was performed using E-testfollowing 2016 CLSI guidelines for interpretation of zones of inhibition. Data entry, transforming and analysis was done using SPSS version 21.
Results: Out of 176 study population 64 were males within 20-60 years of age and 112 were females within 18 to 44 years of age .About 32 (18.2%) N. gonorrhoeae were isolated and fromthese78.1% were from males. The highest frequency (34.4%) of GC infection occurred among 20-24 age group. Frequent alcohol users were seven times in risk than non alcohol user. None ofantimicrobial drug were 100% susceptible to the isolate.
Conclusion and recommendation: the prevalence of gonococcal infection among STI patients relatively high in health centers. Ceftriaxone, Ciprofloxacinand Spectinomycin increasing nonsusceptibility rate. Establishing a national surveillance program might be clarify more of thetreatment response and might be needed guideline review.
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Keywords
Neisseria gonorrhoeae, Non-susceptible, Ethiopia.