Magnitude and drug resistance patterns of Neisseria gonorrhoeae among sexually transmitted infection treated patients in selected health centers of Addis Ababa , Ethiopia.

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Addis Ababa Universty


Background: Gonococcus is a major public health challenge currently, due to the high frequency of infections accompanied by a declining of treatment options. N.gonorrhoeae has repeatedly demonstrated its extraordinary capacity to develop resistance to all antimicrobials introduced for treatment of gonorrhea. Objective: To determine magnitude and drug resistant patterns of Neisseria gonorrhoeae amoung STI treated patients in health centers of Addis Ababa , Ethiopia Methods: A prospective cross-sectional study was done from March-October 2017 at six public health centers of Addis Ababa, Ethiopia. Urethral and Cervical swabs were transported to EPHI microbiology laboratory. Standard microbiological procedures were followed for isolating and identification of N. gonorrhoeae. Antimicrobial sensitivity test was performed using E-test following 2016 CLSI guidelines for interpretation of zones of inhibition. Data entry, transforming and analysis was done using SPSS version 21. Results: Out of 176 study population 64 were males within 20-60 years of age and 112 were females within 18 to 44 years of age .About 32 (18.2%) N. gonorrhoeae were isolated and from these78.1% were from males. The highest frequency (34.4%) of GC infection occurred among 20- 24 age group. Frequent alcohol users were seven times in risk than non alcohol user. None of antimicrobial drug were 100% susceptible to the isolate. Conclusion and recommendation: the prevalence of gonococcal infection among STI patients relatively high in health centers. Ceftriaxone, Ciprofloxacin and Spectinomycin increasing non susceptibility rate. Establishing a national surveillance program might be clarify more of the treatment response and might be needed guideline review.



Neisseria gonorrhoeae, Non-susceptible, Ethiopia.