Magnitude and drug resistance patterns of Neisseria gonorrhoeae among sexually transmitted infection treated patients in selected health centers of Addis Ababa , Ethiopia.
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Date
2018-04
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Addis Ababa Universty
Abstract
Background: Gonococcus is a major public health challenge currently, due to the high frequency
of infections accompanied by a declining of treatment options. N.gonorrhoeae has repeatedly
demonstrated its extraordinary capacity to develop resistance to all antimicrobials introduced for
treatment of gonorrhea.
Objective: To determine magnitude and drug resistant patterns of Neisseria gonorrhoeae amoung
STI treated patients in health centers of Addis Ababa , Ethiopia
Methods: A prospective cross-sectional study was done from March-October 2017 at six public
health centers of Addis Ababa, Ethiopia. Urethral and Cervical swabs were transported to EPHI
microbiology laboratory. Standard microbiological procedures were followed for isolating and
identification of N. gonorrhoeae. Antimicrobial sensitivity test was performed using E-test
following 2016 CLSI guidelines for interpretation of zones of inhibition. Data entry, transforming
and analysis was done using SPSS version 21.
Results: Out of 176 study population 64 were males within 20-60 years of age and 112 were
females within 18 to 44 years of age .About 32 (18.2%) N. gonorrhoeae were isolated and from
these78.1% were from males. The highest frequency (34.4%) of GC infection occurred among 20-
24 age group. Frequent alcohol users were seven times in risk than non alcohol user. None of
antimicrobial drug were 100% susceptible to the isolate.
Conclusion and recommendation: the prevalence of gonococcal infection among STI patients
relatively high in health centers. Ceftriaxone, Ciprofloxacin and Spectinomycin increasing non
susceptibility rate. Establishing a national surveillance program might be clarify more of the
treatment response and might be needed guideline review.
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Keywords
Neisseria gonorrhoeae, Non-susceptible, Ethiopia.