Prevalence of Osteoporosis in Rheumatoid Arthritis Patients and Associated Risk Factors at Tikur Anbassa Specialized Hospital Lancet Specialized Hospital and Rheum Rheumatology and Internal Medicine Specialized Centre, Addis Ababa, Ethiopia
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Date
2025-04
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Addis Ababa University
Abstract
Background: One of the most well known extra articular consequences of RA is osteoporosis (OP), which affects nearly twice as many RA patients as the general population. Approximately 30% of RA patients had osteoporosis, compared to 17% of age and sex matched controls who had the condition. Complex processes, including the generation of inflammatory cytokines, the activation of osteoclasts, and the use of glucocorticoids to treat RA, lead to bone fragility in the disease.
Objective: Assessment of the prevalence and associated risk factors of osteoporosis in rheumatoid arthritis patients at Tikur Anbessa Specialized Hospital, Lancet Specialized Hospital and Rheum Rheumatology and Internal Medicine Specialized Centre.
Methods: A hospital based cross sectional study was conducted at Tikur Anbessa specialized Hospital, Lancet Specialized Hospital and Rheum Rheumatology and Internal Medicine Specialized Centre, from October 1 to November 30. Data were collected using a structured chart review administered questionnaire and data extraction form. Data were analyzed using SPSS V25. To identify associated risk factors in osteoporosis of patients with rheumatoid arthritis, bivariable and multivariable analysis were done. In our study, multivariable analysis was used, a P value of less than 0.05 was considered statistically significant. Text, tables, and graphs were used to convey the results, which were then evaluated to provide useful information.
Results: The prevalence of osteoporosis was 58% among RA patients. The determinant factors of osteoporosis were age >60 compared to age 40 60 years (AOR=10.3), duration of RA >15 years compared to those with duration of RA <15 years (AOR=7.3), use of prednisolone medication (AOR=7.5), and HDL ≤40 mg (AOR=6.1). The continuous variables of age, duration of RA, serum creatinine mg/dl, and diastolic and systolic blood pressure showed a positive significant relationship with BMD.
Conclusion: In this study, the prevalence of osteoporosis was 58% among RA patients. Age, duration of RA, Serum creatinine, and diastolic and systolic blood pressures were significantly associated with increased risk of osteoporosis.
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Osteoporosis