A two-yearretrospective review on theclinical and electrophysiologic profiles of Guillain-Barre Syndrome at two centers in Addis Ababa,Ethiopia
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Date
2020-12
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Addis Abeba University
Abstract
Background: The clinical manifestations and electrophysiologic patterns of Guillain-Barre
Syndrome(GBS)have been established with several studies previously.Nerve conduction study
has been known to be one of the diagnostic tool complementing the clinical presentation of
GBS patients. The aim of this study was to assess the clinical characteristicsand
electrophysiologic pattern of GBSpatients at two facilities in Addis Ababa,Ethiopia.
Methods:A retrospective cross-sectional study was conducted from October 1-30, 2020 upto by
reviewing the medical record of GBS patientswho visited the neurology clinics at two facilities
in Addis Ababa between from September 01, 2017 and September 30, 2019. Demographic,
clinical, biochemical and electrophysiologic data were collected and analyzed.
Results:A total of 59 GBS patients’ medical records were reviewed.Majority 46(72.8%)of the
patients were male.The dominant age category was from 21-35 years of age having 26(44.1%)share.The mean age of the participants was 32.96 (15.04)years .Preceding illnesses were
documented in 21patients wherediarrheal illness was reported by the majority (38%)followed by
upper respiratory tract infections. Quadriparesis was the most frequent presenting symptom with
38(64.4%) patients. .Following the Nerve conduction test the two most common GBS variants
identified were Acute Motor Axonal Neuropathy variant(AMAN)and AcuteInflammatory
Demyelinating Polyneuropathy variants of GBS.
Conclusion: The majority of GBS patientsincluded in our study were young adults who
presented with quadriparesis, with the most common variant of GBS being AMAN variant.
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Keywords
Guillain-Barre Syndrome, Quadriparesis, variants of GBS,Nerve conduction study