Burden of Tuberculosis in Stage 5 Chronic Kdney Disease Patients Undergoing Maintenance Haemodialysis Therapy in Governmental and Non-Governmental Dialysis Centers in Addis Ababa, Ethiopia: A Cross-Sectional Study
No Thumbnail Available
Date
2023-11
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
Background Patients with End stage renal disease appear to be at a higher risk of TB due toimmunosuppression along with socioeconomic, demographic, and comorbidities. Despite high burdenofTuberculosis in developing countries, there is a scarcity of data regarding burden ofTB in ESRD in Ethiopia.
ObjectiveThe objective of this study is to assess the burden of TB in End stage renal patients receiving haemodialysis in Addis Ababa, Ethiopia.
MethodA cross-sectional study was conducted on Burden of Tuberculosis in stage 5 chronic kidney disease patients undergoing maintenance hemodialysis therapy in governmental and non-governmental dialysis centers in Addis Ababa, Ethiopia from August 2022 to October 2022G.C. Patients with a baseline diagnosis of ESRD on HD and age 18 years and above wereincluded in the study. Patients were recruited during their dialysis visit using convenient sampling method and consent was obtained from all participants. A total of 263 participants were included in this study. The diagnosis of ESRD and TB was defined using KDGIO and WHO guidelines. Data were collected through patients interview and reviewing the patient’selectronic medical records. The Collected Data was analyzed using SPSS version 26.0.
Results Our study found a diagnosis of tuberculosis in 71 (27%) of study participants. Among the study participants who was diagnosed with TB, 64 (24.3%) had a previous diagnosis of TB and 12 had active TB.Pulmonary tuberculosis was diagnosed in two-third of TB patients and about third had EPTB, TB lymphadenitis was the commonest followed by pleural TB.Imaging evidence was used to make a diagnosis of TB in one-third patients followed byFNAC (26.6%) and Pleural fluid analysis (26.6%). More than half (54.7%) of TB diagnosiswas made after initiation of haemodialysis. More than half (54.7%) of TB diagnosis was made after initiation of haemodialysis. Having a contact history with a known TB patient, presenceof HIV infection and duration on dialysis for more than 1 year were associated with increased prevalence of TB among CKD patients.
Conclusions Because of its atypical presentation and since it is a mimicker of uremic symptoms, physicians should maintain a high degree of suspicion to consider TB among CKD patients. Early identification and treatment of TB among CKD patients is important in decreasing morbidity and mortality among these patients and in decreasing the transmission of TB among patients who undergo dialysis in the same center. TB preventive therapy should also be considered for this group of patients
Description
Keywords
Tuberculosis End stage renal disease chronic kidney disease dialysis Addis Ababa, , , ,