Assessment of Complete response rate of Post-Thyroidectomy Radioactive Iodine Therapy for Differentiated Thyroid Cancer at Nuclear Medicine center of CHU de Bab El Oued, Algiers, Algeria
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Date
2025-04-11
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Addis Ababa University
Abstract
Background: -. Thyroid cancer is the most common endocrine cancer globally, with a rapidly
increasing incidence rate. Since the most common subtype of thyroid cancer is DTC, which includes
papillary and follicular ca, it has a good prognosis with more than 90% survival rate. RAI treatment
of thyroid cancer is a well-evaluated therapeutic model and is given in combination with surgery
for the purpose of thyroid tissue ablation, adjuvant therapy, and distance metastatic treatment. Even
though the complete response rate of RAI is high, it is affected by different factors, including
histology type, age, lymph node involvement, and so on. Also, the dose and outcome depend on
these factors. Patient can have low risk, intermediate risk, or high risk thyroid cancer disease
category.
Objective: To assess the complete response rate of post thyroidectomy RAI therapy for
differentiated thyroid cancer patients treated in 2021GC (and follow up from January 2021 to
november2024) by using a retrospective study at the Service de Medicine Nucleaire-CHU de Bab
El Oued, Algeria
Methods: Retrospective study in 164 different thyroid cancer patients who underwent thyroidectomy
and took treatment of radioactive iodine in Service de Medicine Nucleaire-CHU de Bab El Oued,
Algeria from January 1/2021 to december31/2021 and follow up from January 2021 to
november2024.Chi- square (χ2) test was used for comparisons categorical variables. To identify
significant predictor univariate logistic regression was conducted at a 25% significance
level. Subsequently, multivariate regression analysis was performed on these variables, with a 5%
significance level.
Result :-A total of 159 patient were included in the study, out of these 144(90.6%) were female and
15(9.%)Were male .Majority of patient were in the age range of 30 to 45 years old (45.9).Complete
response rate of patients was 88%, by which majority of patient reach to this state with in the 1st 2 years
of follow up (82%).lymph node involvement, high base line Tg level, sex, RAI dose was found to have
significant association with complete response outcome but the only independent predictor factor
was found to be having higher baseline Thyroglobulin level.
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Conclusion and recommendation: in this study it is found that patients who have low and
intermediate risk characteristics have good complete response rate, and since there was incomplete
data for some patient who have high risk disease characteristics, it is difficult to conclude about the
complete response rate of high risk patients. The only associated factor which is found to have
independent predictive factor to have low complete response rate is having high baseline
thyroglobulin level. Based on this assessment, since patient with high baseline Tg level has lower
response rate, we recommend giving emphasis to these patients, which might bring better complete
response rate.
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Keywords
RAIT, Thyroid Cancer, DT