Assessment of clinical and hematological alteration among visceral leishmaniasis patients attending Kahsay Abera and Mearg Hospitals, Western Tigrai, Northern Ethiopia, 2019
| dc.contributor.advisor | Dr. Tsegaye, Aster (MSc, PhD) | |
| dc.contributor.author | Gebremichail, Gebremedhin | |
| dc.date.accessioned | 2020-05-21T13:44:47Z | |
| dc.date.accessioned | 2023-11-06T08:56:31Z | |
| dc.date.available | 2020-05-21T13:44:47Z | |
| dc.date.available | 2023-11-06T08:56:31Z | |
| dc.date.issued | 2019-06 | |
| dc.description.abstract | Background: Hematological abnormalities are common in visceral leishmaniasis patients, which is one of the major public health problems worldwide. The most common hematological abnormalities are anemia, leucopenia and thrombocytopenia. Objective: To asses clinical and hematological alteration among visceral leishmaniasis patients attending Kahsay Abera and Mearg Hospitals,Western Tigrai, Northern Ethiopia , 2019 Method: Institutional based comparative cross sectional study was conducted from November 2018 to March 2019 at Kahsay Abera and Mearg hospitals, Western Tigrai, Northern Ethiopia. A total of 100 Visceral Leishmaniasis patients and 100 healthy control groups were included in this study. Blood was collected and analyzed by sysmex KX-21N hematology analyzer. Data was entered and analyzed using SPSS Version 23. Student independent t-test was used for data analysis. P value <0.05 was considered as statistically significant at 95% confidence level. Result: From the total 100 visceral leishmaniasis patients the following abnormalities were reported: 96(96%) anemia, 95(95%) leucopenia, 92(92%) neutropenia, 73(73%) Lymphopenia, 45(45%) eosinopenia and 97(97%) had thrombocytopenia. Splenomegally and fever was seen in all visceral leishimaniasis patients. Red blood cell, hemoglobin, hematocrit, red cell indices and platelet were significantly lower (p<0.05) in visceral leishmaniasis patients compared with the control groups. Similarly the total WBC, neutrophil, lymphocyte, eosinophil and basophil count were significantly lower (p<0.05) in visceral leishmaniasis patients compared with the control groups. Conclusion: The principal changes in peripheral blood of patient with visceral Leishmaniasis are reduced number of red blood cells, reduction in leukocytes and decreased platelet count. VL patients presented with splenomegaly, fever, bleeding, anemia, leucopenia and thrombocytopenia. This finding indicates that visceral leishmaniasis causes alterations of hematological parameters. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/21273 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Amastigote, Anemia, Hematological Parameters, Promastigote, Visceral leishmaniasis, Ethiopia | en_US |
| dc.title | Assessment of clinical and hematological alteration among visceral leishmaniasis patients attending Kahsay Abera and Mearg Hospitals, Western Tigrai, Northern Ethiopia, 2019 | en_US |
| dc.type | Thesis | en_US |