Assessment of Clinical and Hematological Alteration among Visceral Leishmaniasis Patients Attending Kahsay Abera and Mearg Hospitals, Western Tigrai, Northern Ethiopia, 2019
| dc.contributor.advisor | Tsegaye Aster | |
| dc.contributor.author | Gebremichail Gebremedhin | |
| dc.date.accessioned | 2020-05-21T13:44:47Z | |
| dc.date.accessioned | 2023-11-06T08:56:31Z | |
| dc.date.available | 2020-05-21T13:44:47Z | |
| dc.date.available | 2023-11-06T08:56:31Z | |
| dc.date.issued | 2019-06 | |
| dc.description.abstract | Background: Hematological abnormalities are common in visceral leishmaniasis patients, whichis one of the major public health problemsworldwide. The most common hematologicalabnormalities are anemia, leucopenia and thrombocytopenia. Objective: To asses clinical and hematological alteration among visceral leishmaniasis patientsattending Kahsay Abera and Mearg Hospitals,Western Tigrai, Northern Ethiopia , 2019 Method: Institutional based comparative cross sectional study was conducted from November2018 to March 2019 at Kahsay Abera and Mearg hospitals, Western Tigrai, Northern Ethiopia. Atotal of 100 Visceral Leishmaniasis patients and 100 healthy control groups were included in thisstudy. Blood was collected and analyzed by sysmex KX-21N hematology analyzer. Data wasentered and analyzed using SPSS Version 23. Student independent t-test was used for dataanalysis. P value <0.05 was considered as statistically significant at 95% confidence level. Result: From the total 100 visceral leishmaniasis patients the following abnormalities werereported: 96(96%) anemia, 95(95%) leucopenia, 92(92%) neutropenia, 73(73%) Lymphopenia,45(45%) eosinopenia and 97(97%) had thrombocytopenia. Splenomegally and fever was seen inall visceral leishimaniasis patients. Red blood cell, hemoglobin, hematocrit, red cell indices andplatelet were significantly lower (p<0.05) in visceral leishmaniasis patients compared with thecontrol groups. Similarly the total WBC, neutrophil, lymphocyte, eosinophil and basophil countwere significantly lower (p<0.05) in visceral leishmaniasis patients compared with the controlgroups. Conclusion: The principal changes in peripheral blood of patient with visceral Leishmaniasis arereduced number of red blood cells, reduction in leukocytes and decreased platelet count. VLpatients presented with splenomegaly, fever, bleeding, anemia, leucopenia andthrombocytopenia. This finding indicates that visceral leishmaniasis causes alterations ofhematological parameters. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/21273 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Amastigote, Anemia, Hematological Parameters, Promastigote, Visceral leishmaniasis, Ethiopia | en_US |
| dc.title | Assessment of Clinical and Hematological Alteration among Visceral Leishmaniasis Patients Attending Kahsay Abera and Mearg Hospitals, Western Tigrai, Northern Ethiopia, 2019 | en_US |
| dc.type | Thesis | en_US |