Prevalence and Associated Factors of Phenytoin Induced Gingival Overgrowth (Pigo) Among Children Receiving Phenytoin Treatment in Selected Addis Ababa Governmental Hospitals,Ethiopia, Cross-Sectional Study
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Date
2025-02-05
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Addis Ababa University
Abstract
Gingival overgrowth (GO) is a frequent complication associated with various medications, including anticonvulsants such as phenytoin, which is a medication commonly prescribed to treat epilepsy. Other drugs, such as immunosuppressant and calcium channel blockers can also cause GO. Phenytoin is a particularly concerning medication, as it is estimated that 30–50% of patients taking it experience significant gum enlargement. This side effect, known as phenytoin-induced gingival overgrowth (PIGO), can cause considerable cosmetic and functional problems, especially for children, because phenytoin remains widely used, particularly in developing countries. This is reflected in research conducted at Tikur Anbessa Hospital in Addis Ababa, Ethiopia. Among children with epilepsy who were on monotherapy, phenytoin was the most commonly used medication, accounting for 33.6% of the cases. This study investigated the prevalence of PIGO and associated factors among children in Addis Ababa-selected governmental hospitals, which is highly relevant
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PREVALENCE AND ASSOCIATED FACTORS OF PHENYTOIN INDUCED GINGIVAL OVERGROWTH