Molecular Detection of Respiratory Viruses and Bacterial Pathogens Causing Severe Acute Respiratory Infection and Influenza-Like Illness in Under-Five Children at Health Facilities in Ethiopia
| dc.contributor.advisor | Kassu Desta | |
| dc.contributor.advisor | Biruk Zerfu | |
| dc.contributor.advisor | AdamuTayachewu | |
| dc.contributor.author | AdimkewuAgunie | |
| dc.date.accessioned | 2026-11-13T13:11:15Z | |
| dc.date.available | 2026-11-13T13:11:15Z | |
| dc.date.issued | 2026-07-01 | |
| dc.description.abstract | Background: Acute Respiratory Infections (Aris) Are A Major Public Health Concern Globally. The Cause of ARI In Children Under Five Includes Viruses and Bacteria. In Ethiopia Less Coverage of The Influenza Positivity Rate Among Suspected Cases from Both Severe Acute Respiratory Illness (SARI) And Influenza-Like Illness (ILI) Sentinel Sites. However, The Role of Other Causative Pathogens and Bacterial Agents Has Not Been Comprehensively Investigated. This Study Aims to Investigate Viral and Bacterial Etiology from SARI And ILI Cases in Children Under 5 Years of Age in Ethiopia. Objective: To Assess Common Respiratory Viruses and Bacterial Pathogens Causing Severe Respiratory Infection and Influenza-Like Illness in Children Under Five Years Old at Health Facilities Serving as Influenza Sentinel Sites in Ethiopia. Methods: This Study Employed a Cross-Sectional Study Design. Epidemiological Data and Throat, Nasal, And Nasopharyngeal Swab Samples Were Collected From 14 Influenza Sentinel Sites for Influenza Surveillance from January to April 2026. After Testing for Influenza, Select All Samples Under 5, Extract, And Perform Detection at the Influenza National Reference and Referral Laboratory of the Ethiopian Public Health Institute (EPHI). A Chi-Squared Test Was Used to Compare Differences, And A Bivariate Logistic Regression Analysis Was Used for Associated Factors with Independent Variables. Result: A Total Of 422 Children Under Five Were Tested Across 14 Ethiopian Influenza Sentinel Sites, Which Found That (131) 31% Were Positive For At Least One Viral Pathogen And (156)37% For At Least One Bacterial Pathogen, With the Highest Burden Concentrated in Infants Under Two Years. Human Adenovirus (32) 7.5%, Influenza (27) 6.4%, And RSV (19) 4.5% Were the Leading Viral Pathogens, While Haemophiles Influenzae (84) 20% And Streptococcus Pneumoniae (58)13.8% Dominated the Bacterial Pathogen Findings. A Viral Co-Detection Rate Of 20 Of 131 (15.2%) Was Recorded, And A Bacterial-Viral Co-Detection Rate Of 4.6% Of the Total 64 Co-Detections; This Finding Underscores the Remarkable Complexity of Pediatric Respiratory Illness in Ethiopia. Conclusion: This Study Detected the Circulation of Viral and Bacterial Pathogens Causing SARI And ILI In Children Under Five, And It Confirms That Adenovirus, Influenza, RSV, H. Influenzae, And S. Pneumoniae Are the Dominant Etiological Agents. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/9589 | |
| dc.language.iso | en | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Multi-Co-Ari | |
| dc.subject | Co-Mari | |
| dc.subject | Car-Multi | |
| dc.subject | Marc-Ari. | |
| dc.title | Molecular Detection of Respiratory Viruses and Bacterial Pathogens Causing Severe Acute Respiratory Infection and Influenza-Like Illness in Under-Five Children at Health Facilities in Ethiopia | |
| dc.type | Thesis |