Multi-Drug Resistant Bacterial Isolates Among Septicemia Suspected Under Five Children In Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia
| dc.contributor.advisor | Desta Kassu | |
| dc.contributor.author | Mitiku Mequanint | |
| dc.date.accessioned | 2018-11-19T04:04:44Z | |
| dc.date.accessioned | 2023-11-06T08:56:21Z | |
| dc.date.available | 2018-11-19T04:04:44Z | |
| dc.date.available | 2023-11-06T08:56:21Z | |
| dc.date.issued | 2018-07 | |
| dc.description.abstract | Background: Bloodstream infections due to bacterial pathogens are a major cause of morbidityand mortality among pediatric patients. Emergence of drug resistance in high classes ofantibiotics among the bacterial pathogens is another issue of the public health concern. Objective: To determine Multi-Drug Resistant Bacterial Isolates among Septicemia Suspectedunder Five Children in Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia. Methods: Across-sectional study was conducted from September 2017 to June 2018 amongpediatric patients with febrile illness aged under five in Tikur Anbesa Specialized Hospital.Three hundred forty blood samples were collected and processed following standardmicrobiological techniques and culture was performed using BacT/Alert machine in combinationwith conventional method. Antimicrobial susceptibility testing of the isolates was performed byKirby-Bauer disc diffusion method and MIC technique Result: A total of 137(40.2%) bacterial pathogens were isolated from 340 pediatric patientssuspected of BSI with febrile illness. Of these isolates, about 46% of them were Gram positiveand 54% were Gram negative bacteria. Of the isolates 43 (31.4%) Klebsiella pneumoniae,29(21.2%) S. aureus, 15(10.9%) CoNS and 12 (8.7%) Acinitobactor species were the mostfrequently isolated pathogens. The overall prevalence of MDR 51.1%, CRE 30.5% and ESBL25.4% were alarmingly high in bacterial isolates. Klebsiella pneumoniae isolates were 95.6%MDR, 23.7% ESBL, and 27.1% CRE dominated followed by Staphylococcus aureus 55.2%MRSA in children. Conclusion and Recommendation:In this study, Klebsiella pneumoniae and S. aureus are common pathogens associated with BSIin pediatrics with high antimicrobial resistance. High frequency of staphylococcus species andMRSA were a treat of children. Emergency of an intermediate vancomycin susceptibility of anisolate among MRSA calls an attention on treatment options. ESBL producing organisms werecommon in Klebsiella species and Escherichia coli isolates. Since most of isolates exhibitmultidrug resistant, routine in-vitro susceptibility of antimicrobials and update antibiogram fortreatment is essential. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/14370 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Ababa Universty | en_US |
| dc.subject | Blood stream infection, BacT/Alert, multi-drug resistance, ESBL, MRSA, CRE, VRSA | en_US |
| dc.title | Multi-Drug Resistant Bacterial Isolates Among Septicemia Suspected Under Five Children In Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia | en_US |
| dc.type | Thesis | en_US |