Multi-Drug Resistant Bacterial Isolates Among Septicemia Suspected Under Five Children In Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia

dc.contributor.advisorDesta, Kassu (MSc, PhD candidate)
dc.contributor.authorMitiku, Mequanint
dc.date.accessioned2018-11-19T04:04:44Z
dc.date.accessioned2023-11-06T08:56:21Z
dc.date.available2018-11-19T04:04:44Z
dc.date.available2023-11-06T08:56:21Z
dc.date.issued2018-07
dc.description.abstractBackground: Bloodstream infections due to bacterial pathogens are a major cause of morbidity and mortality among pediatric patients. Emergence of drug resistance in high classes of antibiotics among the bacterial pathogens is another issue of the public health concern. Objective: To determine Multi-Drug Resistant Bacterial Isolates among Septicemia Suspected under Five Children in Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia. Methods: Across-sectional study was conducted from September 2017 to June 2018 among pediatric patients with febrile illness aged under five in Tikur Anbesa Specialized Hospital. Three hundred forty blood samples were collected and processed following standard microbiological techniques and culture was performed using BacT/Alert machine in combination with conventional method. Antimicrobial susceptibility testing of the isolates was performed by Kirby-Bauer disc diffusion method and MIC technique Result: A total of 137(40.2%) bacterial pathogens were isolated from 340 pediatric patients suspected of BSI with febrile illness. Of these isolates, about 46% of them were Gram positive and 54% were Gram negative bacteria. Of the isolates 43 (31.4%) Klebsiella pneumoniae, 29(21.2%) S. aureus, 15(10.9%) CoNS and 12 (8.7%) Acinitobactor species were the most frequently isolated pathogens. The overall prevalence of MDR 51.1%, CRE 30.5% and ESBL 25.4% were alarmingly high in bacterial isolates. Klebsiella pneumoniae isolates were 95.6% MDR, 23.7% ESBL, and 27.1% CRE dominated followed by Staphylococcus aureus 55.2% MRSA in children. Conclusion and Recommendation: In this study, Klebsiella pneumoniae and S. aureus are common pathogens associated with BSI in pediatrics with high antimicrobial resistance. High frequency of staphylococcus species and MRSA were a treat of children. Emergency of an intermediate vancomycin susceptibility of an isolate among MRSA calls an attention on treatment options. ESBL producing organisms were common in Klebsiella species and Escherichia coli isolates. Since most of isolates exhibit multidrug resistant, routine in-vitro susceptibility of antimicrobials and update antibiogram for treatment is essential.en_US
dc.identifier.urihttp://etd.aau.edu.et/handle/123456789/14370
dc.language.isoen_USen_US
dc.publisherAddis Ababa Universtyen_US
dc.subjectBlood stream infection, BacT/Alert, multi-drug resistance, ESBL, MRSA, CRE, VRSAen_US
dc.titleMulti-Drug Resistant Bacterial Isolates Among Septicemia Suspected Under Five Children In Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopiaen_US
dc.typeThesisen_US

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