Transport Driven by a Random Telegraph force in an Asymmetric Membrane Channel
| dc.contributor.advisor | Bekele, Mulugeta (PhD) | |
| dc.contributor.author | Kassa, Yibekal | |
| dc.date.accessioned | 2018-07-09T12:33:33Z | |
| dc.date.accessioned | 2023-11-09T11:25:01Z | |
| dc.date.available | 2018-07-09T12:33:33Z | |
| dc.date.available | 2023-11-09T11:25:01Z | |
| dc.date.issued | 2010-09 | |
| dc.description.abstract | Channel proteins that selectively conduct molecules across the cell membrane often exhibit an asymmetric structure. By means of a stochastic model the channel asymmetry in the presence of non equilibrium fluctuations can influence the transport through such channels by a ratchet like mechanism. In general, the ratchet effect refers to the generation of directed motion of Brownian particles in a spatially asymmetric (ratchet) potential in the presence of non equilibrium fluctuations and externally applied time periodic force with mean zero. Using this structure, Schulten and Kosztin [1] have numerically studied the behavior of steady state flux by considering various cases of an external tilting force. Being interested in seeking analytical results, we model the potential of the channel by a ratchet like potential and obtain analytical expressions for the steady state flux of glycerol through the channel due to a concentration gradient, constant force, periodically switching force and non equilibrium fluctuations of the cell membrane. In addition we compare our results with the numerical results obtained in [1] | en_US |
| dc.identifier.uri | http://10.90.10.223:4000/handle/123456789/7398 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Transport Driven by a Random | en_US |
| dc.title | Transport Driven by a Random Telegraph force in an Asymmetric Membrane Channel | en_US |
| dc.type | Thesis | en_US |