Assessment of Specimen Rejection Rate and Associated Factors among Samples Referred to Addis Ababa Research and Emergency Management Core Process Laboratory, Addis Ababa, Ethiopia
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Date
2021-02
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Addis Abeba University
Abstract
Background: Accurate laboratory results are vital for patient safety and improving the medical
diagnosis. Most errors occurred in the pre-analytic phase. Improper collection of samples can
lead to sample rejection. In this case laboratory should establish rejection criteria and follow
them closely. Specimen rejection may have significant consequences for patients and their
clinical management. Thus, understanding the magnitude and taking appropriate action is critical
for quality laboratory service provision.
Objective: to assess the Specimen rejection rates and associated factors among samples referred
to the laboratory of Addis Ababa Research and Emergency Management core process.
Methods: cross sectional study was conducted using both primary and secondary data which
assesses the rate and reason of rejection observed from June 01, 2018 to May 30, 2020 G.C.
About 131,909 specimens collected at Addis Ababa Research and Emergency management core
process laboratory with in the period of the study was entered and analyzed using SPSS 20.
Result: a total of 131,909 specimens were sent to central reception of the Addis Ababa public
health research and Emergence management core processes laboratory. The total rejection rate
was 0.69%, 915. The frequencies of rejected specimens were highest in viral load 35.1%,
followed by clinical chemistry which was 23.4%. The most common reason of rejection was
mislabeling, 27.1%, followed by insufficient 15.8%, and clotted 15.1% specimen. Among
rejected specimens, 514 specimens were rejected in the first and 401 Specimens were rejected in
the second.
Conclusions: The study demonstrated about 0.7% specimen rejection rate. Alongside of the
efforts to minimize laboratory error, this study highlighted a complexity of pre-analytical errors
to minimize them. The most commonly rejected specimens were for viral load followed by
clinical chemistry samples. The most common pre analytical reason for specimens’ rejection was
mislabeling, followed by insufficient and clotted specimens.
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Keywords
Specimen rejection, Pre-analytic phase, Clinical laboratory, Error