Surgical outcome of Open Liver Resection for HCC: A Multi-Center Prospective Study, an Experience from Low Income Country
| dc.contributor.advisor | Zeki Abdurrahman | |
| dc.contributor.author | Yitagesu Aberra | |
| dc.date.accessioned | 2025-03-20T13:53:51Z | |
| dc.date.available | 2025-03-20T13:53:51Z | |
| dc.date.issued | 2024-12-13 | |
| dc.description.abstract | Introduction: The most common primary malignant liver tumor is hepatocellular carcinoma.it commonly occurs in cirrhotic liver caused by viral infection. There are different management options depending on the tumor burden, performance status of the patient and status of background liver. Liver resection is one of them, with a cure intent intervention, which is the only option we have in Ethiopia. The morbidity and mortality associated with liver resection is decreasing with advent in surgical techniques and improved post-operative care in developed nations.in Ethiopia hepatic resection has been done for decade but its outcome never been studied before. This research will be the first to assess hepatic resection outcome for HCC and serve as a mirror to see the outcome of our surgical practice and compare our stance in the realm of hepatic resection and HCC care. Objective: of the study Evaluate Post-operative morbidity and length of hospital stay of hepatic resection for HCC at different tertiary hospitals in Addis Ababa between June, 2022 and June, 2024 GC. Methodology: of the study A Two-year prospective multi-center cohort study was conducted from June, 2022 - June 2024 at tertiary referral hospitals in Addis Ababa. Descriptive analysis was done using frequency and cross tabulation parameters. univariate and multivariate logistic regression was done to see association between post-operative complication and independent variables whereas multiple linear regression was used to see association between length of hospital stay and independent variables. Result: There were 101 patients analyzed who undergone Hepatic resection for HCC in the study population. the mean age was 57.42yrs with equal sex distribution. Hypertension (23.8), diabetes mellitus (17.8) and viral infection (39.6%) are the most common comorbidities and risk factor identified. most are right side (58.4%) solitary tumor (79.2%) with a mean tumor size of 6.74cm occurring in Cirrhotic/fibrotic liver in 47.5% of the case. With a rate of higher major (34%) resection and Non-anatomic resection (22.8%) a mean intraoperative blood loss of 849.01 (SD=472.915), transfusion rate of 51.8%, mean intra-operative fluid intake of 2289.74 (SD=809.937) was identified and took a mean operative time of 2.90hr (SD=0.943). there were vii 48.8% complication rate and most of them were Minor (CD Grade 1 and 2=83.1%) and procedure related complications (79.8%) with hepatic insufficiency/failure being the most common specific complication (22.8%). Major resection (AOR=2.576, P-value-0.002), right Hepatectomy (AOR=2.676, P-value | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/5140 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Hepatic resection Hepatocellular carcinoma surgical outcome Post-Hepatectomy liver failure liver | |
| dc.title | Surgical outcome of Open Liver Resection for HCC: A Multi-Center Prospective Study, an Experience from Low Income Country | |
| dc.type | Thesis |