Bioactive metabolites from the cultures of Phellinus sp. and Lentinus velutinus
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Date
1994-06
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Addis Ababa Universty
Abstract
The ethyl acetate extract of the fermentation culture broth of Phellinus sp. gave two i
compounds identified as3-chloro-4-methoxybenzaldehydeand 3,4-dimethoxybenzaldehyde.
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Both 3-chloro-4-methoxybenzaldehyde and 3,4-dimethoxybenzaldehydeshowed phytotoxic j i
activity and lethality to brine shrimp ( Artemia salina Leach) but 3,4- ji
dimethoxybenzaldehyde showed weaker activity. Both 3-chloro-4-methoxybenzaldehyde
and 3,4-dimethoxybenzaldehyde were isolated for the first time from the genus Phellinus.
The structures were elucidated by spectral analyses and synthesis. A fatty acid and a
triglyceride were also isolated from the Phellinus sp. grown on rice. !
The ethyl acetate extract of the fermentation culture broth of Lentinus velutinus gave rise
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to three compounds of which two were identified as the antibiotic compounds hypnophilin
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and velutinol and the third as the antitumour compound panepoxydon. Velutinol was j
reported earlier from the culture filtrate of the same fungus, however, hypnophilin and
panepoxydon have not hitherto been reported from the genus Lentinus.
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Keywords
Fermentation culture broth of Phellinus sp.