Bioactive metabolites from the cultures of Phellinus sp. and Lentinus velutinus

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Date

1994-06

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Addis Ababa Universty

Abstract

The ethyl acetate extract of the fermentation culture broth of Phellinus sp. gave two i compounds identified as3-chloro-4-methoxybenzaldehydeand 3,4-dimethoxybenzaldehyde. I Both 3-chloro-4-methoxybenzaldehyde and 3,4-dimethoxybenzaldehydeshowed phytotoxic j i activity and lethality to brine shrimp ( Artemia salina Leach) but 3,4- ji dimethoxybenzaldehyde showed weaker activity. Both 3-chloro-4-methoxybenzaldehyde and 3,4-dimethoxybenzaldehyde were isolated for the first time from the genus Phellinus. The structures were elucidated by spectral analyses and synthesis. A fatty acid and a triglyceride were also isolated from the Phellinus sp. grown on rice. ! The ethyl acetate extract of the fermentation culture broth of Lentinus velutinus gave rise i to three compounds of which two were identified as the antibiotic compounds hypnophilin J and velutinol and the third as the antitumour compound panepoxydon. Velutinol was j reported earlier from the culture filtrate of the same fungus, however, hypnophilin and panepoxydon have not hitherto been reported from the genus Lentinus.

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Fermentation culture broth of Phellinus sp.

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