The Effect of Zinc Exposure on the Histology of Liver and Kidney
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Date
2014-07
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Addis Abeba University
Abstract
Zinc is one of the most important trace elements in the body that participates in the biological function of several proteins and enzymes. Despite the fact that small quantity of zinc is required for the normal development and metabolism, its effect is toxic when a certain concentration is exceeded. The aim of this paper is to review scientific literatures on the protective and toxic effect of zinc exposure on the histology of liver and kidney. The studies were evaluated in relation to dose of zinc, zinc combination with other toxic metals, duration of exposure, type of animal model used, method of study used and parameter used to measure protective effect of zinc against toxic metals and toxic effect of zinc alone. The different literatures reviewed in this paper used rats, mice, lambs, fishes, ducks. The literature reviewed showed that Zn administration together with Al, Cd, as well as organic solvent such as ethanol has a protective effect against Al, Cd induced toxicity in liver and kidney tissues and ethanol induced toxicity in liver tissue. On the other hand, as zinc dose level and duration of the exposure increases, it act as toxic metal to histology of liver and kidney.
Key words: zinc, liver, kidney
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Zinc, Liver, Kidney