Assessment of Immuno-Hematological Parameters Among Adult Hiv Positive Patients Before and After Initiation of 1j Highly Active Antiretroviral Treatment Regimen at St. Peter Specialized Hospital, Addis Ababa, Ethiopia
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Date
2022-06-16
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Addis Ababa University
Abstract
Background: Immuno-Hematological abnormalities are common in human immunodeficiency virus (HIV) infected individuals before and after ARV treatment However, the Immuno-hematological outcome of ARV treatment initiated usage is not well investigated.
Objectives: To assess hematological and CD4+ parameters among Adult HIV positive patient before and after initiation of ARV TREATMENT treatment at St. Peter specialized Hospital, Addis Ababa, Ethiopia, 2021.
Methods: Cross-sectional study was conducted from May to July, 2021 at St. Peter Specialized Hospital among Adult HIV positive patients. A total of Adult 422 HIV patients on ARV treatment for at a minimum of 3 months were selected using convenient sampling methods. Socio-demographic as well as clinical data of the participants was obtained using pre-tested structured questionnaires and review of medical records. Hematological parameters such as CBC was obtained using Beckman Coulter (DxH800) automated Hematology Analyzer and CD4+ parameter such as CD4 count was determined using BD FACS presto. Statistical analysis of the data was done using SPSS version 21. Paired t-test was used to compare dependent variables before and after initiation of ARV treatment and Binary Logistic regression Results: Of Adult 422 HIV positive individuals, about 64.7% were females. The mean age of study participants were42.16 (SD=±10.4years). The mean WBC, LYM, RBC, NEU, PLT, Hb and CD4, significantly improved after 3 months of ARV treatment. While, MCH and RDW significantly decreased after 3 months of ARV treatment without showing a significant improvement in MCV, HCT, MCHC, MPV and PDW after ARV treatment. On the other hand, the most common Hematological abnormalities detected were anemia (12.1), followed by Neutropenia (6%) and Thrombocytopenia (4%). Anemia was associated with Female Sex (AOR7.8, 95% CI:1.9-32.2, pwas used to determine predictors of detected Immuno-Hematological abnormalities. P-value.
Conclusion: There was a significant change in certain CD4+ and hematological parameters after initiation of the ARV treatment. Further studies are required to fully comprehend the outcome of the ARV regimen on hematological and CD4+ parameters.
Key words: Immuno-hematological, ARV treatment, Adult HIV Patients
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Keywords
Immuno-hematological ARV treatment Adult HIV Patients