Assessment of hematological and biochemical alteration in type II diabetes mellitus patients attending Aksum St. Marry Hospital, Aksum, Northern Ethiopia
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Date
2021-09
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Addis Abeba University
Abstract
Background: Diabetes mellitus is a non-communicable disease that has a high prevalence
worldwide. Altered level of many hematological and biochemical parameters have been
observed in patients with diabetes. Although type ӀӀ diabetes mellites alters hematological and
biochemical parameters, so far, very little work has been done in Ethiopia linking hematological
parameters and biochemical markers with type ӀӀ diabetes mellites patients.
Objective: To assess alteration of hematological and biochemical parameters in type ӀӀ diabetes
mellitus patients attending Aksum St. Marry Hospital, Aksum, Northern Ethiopia, from
December 2019-April 2020
Method: comparative cross-sectional study was conducted from December 2019 to April 2020 at
Aksum St. Marry Hospital, Aksum, Northern Ethiopia. A total of 168 participants were enrolled
using convenient sampling method. Socio-demographic, behavioral and physical measurement
data were collected. Complete blood count was performed by sysmex KX-21N hematology
analyzer. The biochemical parameters were analyzed by using BE200. Data was analyzed using
SPSS 23. Student independent t-test and person’s correlation statistical method employed to
analyze data. P values < 0.05 was regarded as statistically significant at 95% confidence level.
Result: Among the hematological parameters WBC count, neutrophil count, lymphocytes count,
platelet count, MPV significantly increased. Similarly, RBC count, hemoglobin and PCV
showed significant decrease in T2DM patients compared to controls. With regard to biochemical
parameters ALT, AST, ALP, Creatinine and urea showed significantly increasing in T2DM
patients when compared to controls. Regarding correlation, WBC with BMI and MCHC with
FBS had positive correlations.
Conclusion: There is alteration in total WBC, neutrophil, lymphocyte, eosinophil, basophil,
RBC, hemoglobin and PCV. Also, from biochemical parameters ALT, AST, ALP, urea and
creatinine altered in diabetes patients compared with control group.
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Keywords
Type ӀӀ diabetes mellitus, hematological parameters, biochemical parameters, hyperglycemia, study area