Assessment of Factors Affecting Adherence and Utilization of Isoniazid Preventive Therapy among HIV Patients Yekatit 12 Hospital, Addis Ababa
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Date
2014-02
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Addis Ababa University
Abstract
Background: Isoniazid (INH) is given to individuals with latent infection of tuberculosis in order to prevent progression to active disease. It is important to understand factors associated with non-adherence so that high adherence can be maintained or low adherence improved since adherence to effective treatment improves health outcomes.
Objective: To assess factors affecting adherence and utilization of IPT in HIV patients and to explore the opinions of patients and health care providers about factors affecting adherence and use of INH
Methods: Participants eligible for the study 403 individuals who were HIV positives taking INH on follow up at yekatit 12 hospital randomly selected and Adherence measured by self-report of INH tablets taken for past 3, 7 and 30 days and in depth interview for recruited patients, adherence counselor and health professionals at ART clinic was done.
Results: Adherence to INH was 94% by self-report for last 7 days .The odds of adherence to INH was 7.7 [95% CI (2.6, 22.9)]times higher among those with no skin rash compared to patients with skin rash.
Conclusion: The prevalence of adherence to INH among people living with HIV in yekatit 12 hospital has a better rate of adherence than other local and African studies and the reasons for poor adherence was strongly associated with occurrence of jaundice, skin rash and seizure and rate of utilization is perceived to be low because of interrupted drug supply.
Recommendation: Availability of comprehensive care and support such as nutritional support and appointment per demand adequate time for counseling, follow up, sustainable drug supply, evaluation and treatment of side effects
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Therapy among HIV Patients