Assessment of Coagulation Profile among Adult Cardiac Outpatient Department of Tikur Anbessa Hospital, Addis Ababa, Ethiopia.
No Thumbnail Available
Date
2021-02
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background; the coagulation process is initiated by platelets forming a plug at the location of
the injury within few seconds of a breach in the vascular integrity. This constitutes the primary
haemostatic mechanism. Secondary homeostasis is a multifaceted interaction between plasma
coagulation factors, which results in the creation of fibrin strands strengthening the platelet plug.
A hospital based cross sectional (retrospective chart review) study design was employed and
simple random sampling techniques was used. Sample size is calculated by taking assumptions
of 95% confidence level, there is no other study conducted related with this title to being use as a
reference proportion so I took 50% (P=0.5) as a reference proportion. And adding 10 % nonrespondents
rate.
The
total
population
under
study,
which
means
total
patient
number
who
attend
cardiac
clinic in last month, was 1000 so by using correction formula the sample size becomes
306.
In this study we found that the mean INR value of a patient under study was 3.037 (SD: ±1.43)
and the median was 2.9.While the quarantines was 2.0 – 3.65. According to our study, the data
confirmed that the mean platelet count of the study unit was 282248(SD: ±89589). However, the
mean PTT value of patients was 41.7 seconds (SD: ±11seconds). While the minimum PTT was
22 seconds and the maximum was 77 seconds. as this study is hospital based with limited
representativeness population based studies are recommended.
Description
Keywords
Coagulation profile, platelets, hemostasis