Clinico Pathological Patterns and Treatment Outcomes of Pediatric Germ Cell Tumors Treated at Tikur Anbessa Hospital: A 10-Year Single Tertiary Hospital Experience
| dc.contributor.advisor | Arega,Gashaw(MD, MPH) | |
| dc.contributor.author | Gebrehiwot,Mihret | |
| dc.date.accessioned | 2025-08-12T15:27:49Z | |
| dc.date.available | 2025-08-12T15:27:49Z | |
| dc.date.issued | 2024-04 | |
| dc.description.abstract | Background:Pediatric Germ Cell Tumors (GCTs) are rare heterogeneous neoplasms with a peak incidence in children younger than 4 years old and during adolescence. The clinical presentation and treatment outcomes of GCTs are not well-studied in developing countries. The main aim of this study was to assess the clinic-pathological patterns and treatment outcomes of Pediatric Germ Cell Tumor (GCT) patients treated at Tikur Anbessa Specialized Hospital. Methods: A retrospective, cross-sectional study was conducted at Tikur Anbessa Specialized Hospital on Pediatric Germ Cell tumor patients treated from January 1, 2014, to December 31, 2023. The collected data were analyzed using a statistical package for social sciences (SPSS) version 25. The Kaplan–Meier Survival estimate was used to assess the Overall Survival (OS) and Event-Free Survival (EFS). Results: A total of ninety-one patients were included in the study. The median age at diagnosis was 4 years with a female-to-male ratio of 2.3:1. Most patients were under five years of age; constituting 61.6% (n=56). The duration of the illness from the onset of symptoms to the oncologic treatment center ranged from 2 days to 12 months with a mean duration of four months. Sacrococcygeal swelling was the commonest presenting symptom accounting for 38.2% (n=34) followed by abdominal mass (36%). Most of the patients had extracranial GCTs constituting 93.4% (n=85). Mature teratoma was the most common histology of GCTs constituting 52.6% followed by dysgerminomas (17.1%, n=13). About 42% of patients received a combination of chemotherapy and local control measures either surgery or radiotherapy. The Kaplan-Meier survival estimates showed the first and five-year OS was 95.7% and 85%, respectively. The first and five-year EFS was 95% and 84 % respectively. Conclusion:Our study showed the mean duration of the illness from the onset of symptoms to the oncologic treatment center was 4 months. Mature teratoma was the commonest histology. The 1-year and 5- year OS probabilities were better than other studies in similar settings. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6343 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Germ cell tumors | |
| dc.subject | Pediatric | |
| dc.subject | Histology | |
| dc.subject | Chemotherapy | |
| dc.subject | treatment outcome | |
| dc.subject | Ethiopia | |
| dc.title | Clinico Pathological Patterns and Treatment Outcomes of Pediatric Germ Cell Tumors Treated at Tikur Anbessa Hospital: A 10-Year Single Tertiary Hospital Experience | |
| dc.type | Thesis |