Evaluation of anti-hyperglycemic effect of hydroethanolic extract of Foeniculum Vulgare (“Ensilal”) seed on alloxaninduced Diabetic male Wistar albino rats.
| dc.contributor.advisor | Dr. Genet, Solomon(PhD) | |
| dc.contributor.author | Tigstu, Feven | |
| dc.date.accessioned | 2020-03-23T11:42:39Z | |
| dc.date.accessioned | 2023-11-29T04:18:22Z | |
| dc.date.available | 2020-03-23T11:42:39Z | |
| dc.date.available | 2023-11-29T04:18:22Z | |
| dc.date.issued | 2019-12 | |
| dc.description.abstract | Background: - Diabetes mellitus (DM) is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from inherited and acquired deficiency in production of insulin by the pancreas, and due to resistance to insulin’s effects. DM is one of the leading causes of death, disability, illness, and economic loss in the world. Nowadays herbal medicines have become a good alternatives for the treatment of hyperglycemia. Ethiopia has many plants that are useful in the treatment of different diseases from those fennel has a potential in reducing the hyperglycemic state during diabetes. Objective: - To evaluate the anti-hyperglycemic effect of Foeniculum vulgare (fennel) seed hydro-ethanolic extracts on alloxan-induced diabetic male Wistar albino rats. Method: -Thirty-six male Wistar albino rats with a weight of 180-250 grams were induced with diabetes using 175mg/kg alloxan monohyderate. After grouping, experimental rats were given daily oral administration of hydro - ethanolic extract of Foeniculum vulgare seed (100, 200 and 400mg/kg) for 21consecuative days. Fasting blood sugar, total cholestrol, triglyceride, alanine aminotransferase, aspartate aminotransferase and histopatology of liver was assessed. Glibenclamide was used as a standard reference drug. Additionally in vitro study conducted on Free radical scavenging and α amylase inhibitory activity of the Foeniculum vulgare seed hydroethanolic extract was also investigated. Result: - Foeniculum vulgare seed hydro-ethanolic extract showed a highly significant blood- glucose-lowering effect. After induction of diabetes, rats treated with 400mg/kg extract respond in a better, gradual, and statistically significant way to reduce mean blood glucose levels from 352 mg/dl on day 0 to 189.1 mg/dl on 21 st day. In addition, a significant reduction was observed in total cholesterol, triglyceride, alanine aminotransferase and aspartate aminotransferase analysis also, liver abnormality restoration were seen in histopatological study. Besides, good anti- oxidative and α amylase inhibitory activity was shown from the in vitro lab tests. Conclusion: - The result of the experiment showed that Foeniculum vulgare seeds may have several bioactive secondary metabolites effective in lowering blood glucose levels and increasing body antioxidants. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/21220 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Diabetes mellitus, Alloxan, Foeniculum vulgare, Wistar albino rats | en_US |
| dc.title | Evaluation of anti-hyperglycemic effect of hydroethanolic extract of Foeniculum Vulgare (“Ensilal”) seed on alloxaninduced Diabetic male Wistar albino rats. | en_US |
| dc.type | Thesis | en_US |