Treatment outcome and associated factors in acute heart failure patients at Tikur Anbessa Specialized Hospital, Ethiopia
No Thumbnail Available
Date
2018-02
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa Universty
Abstract
Treatment outcome and associated factors in acute heart failure patients at Tikur Anbessa
Specialized Hospital, Ethiopia
Mulubirhan Tirfe Tesfay
Addis Ababa, Ethiopia
February 2018
Heart failure is a syndrome when the heart fails to pump blood at a rate commensurate with
the requirements of the body. Acute heart failure is a recent worsening of sign and symptom
of heart failure requiring emergency visit and hospitalization. The aim of this study was to
evaluate treatment outcome and associated factors that predict poor treatment outcome in
acute heart failure patients at emergency department and medical ward. A prospective
observational study was designed to evaluate predictors of poor treatment outcome. Data was
reported as mean ± SD for continuous variables with normal distributed and median (interquartile
range) with non-normal distributed variables; and chi square test was used for
categorical variables. Bivariate and multivariate logistic regression analysis was used to
evaluate factors that predict poor treatment outcome; p-value ≤ 0.05 was considered
statistically significant and reported as 95% CI. Statistical package for social science (SPSS
version 20) was used to enter and analyze data. The median age of patients with acute heart
failure was 34 years (IQR = 23 to 50) and median hospital stay was four days (IQR = 3 to 6)
with female (54.4%) dominance. The leading precipitating factor and underlying disease
found at admission were pneumonia (47.5%) and chronic rheumatic heart disease (48.5%),
respectively. Out of the 169 patients, 17.2% had poor treatment outcome among these six
(3.6%) patients died. In multivariate logistic regression analysis smoking (adjusted odds ratio
[AOR] = 8.7, p = 0.006), diabetes mellitus (AOR = 10.2, p = 0.005), pulmonary hypertension
(AOR = 4.3, p = 0.016) and presence of adverse drug events (AOR = 4.2, p = 0.003) were
predictors of poor treatment outcome.
Description
Keywords
acute heart failure; predictor; treatment outcome