Hematological and Lipid Profiles Before and After Statin Treatment in Patients with Dyslipidemia at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia: Retrospective Cohort and Cross-Sectional Study
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Date
2024-07-13
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Addis Ababa University
Abstract
Background: Dyslipidemia is a plasma lipid abnormality. Statins are a widely used lipid lowering drug. Previous studies have demonstrated the association of hematological parameters with lipid profiles and the effect of statin on these parameters. However, the results are still controversial and their application in clinical practice is limited, so this study was conducted to improve the significance of hematological parameters in dyslipidemia patients.
Objective: To determine the effect of statin treatment on hematological parameters in patients with dyslipidemia from August to November, 2023 at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
Methods: A cross-sectional study from August to November 2023 was conducted at St. Paul’s Hospital Millennium Medical College, Ethiopia. Patients with dyslipidemia, 158 who have been taking statin for at least 3 months and 158 controls who monitor their serum lipids by lifestyle modification were enrolled in the study. They were selected by a convenient sampling
method. Hematological and lipid profiles were analyzed by Beckman Coulter and Cobas 6000 analyzers, respectively. The data was analyzed using SPSS version 23. The normality of the data was checked by the Kolmogrov-smimov test. A parametric or non-parametric test was used for data analysis. All statistical significance was considered at p < 0.05.
Result: A total of 316 dyslipidemia patients, 158 on statin treatment for at least three months, and 158 statin naive controls were participated in the study. The majority of them had diabetes and hypertension. After the treatment, total cholesterol, low-density lipoprotein (LDL-C), and triglyceride were reduced significantly. White blood cell (WBC), red cell distribution width (RDW), and mean platelet volume decreased (MPV) (from 7.01±.1.6 to 6.7±1.6, 14.1±1.08 to 12.8±0.7, and 10.04±1.15 to 9.70±.99, respectively) with a p-value < 0.05. The change observed in RDW showed a correlation with the change that occurred in LDL-C.
Conclusion: the study showed difference before and after Statin Treatment in Patients with Dyslipidemia on WBC, MPV and RDW parameters values; hence, these parameters could be used as additional tools to monitor patient status after statin treatment.
Key words: hematological profile, dyslipidemia, statin