Treatment Outcome of Drug-resistant Tuberculosis and Associated Factors at St.peter Specialized Hospital Addis Ababa, Ethiopia.
| dc.contributor.advisor | Prof. Hailu, Asrat | |
| dc.contributor.advisor | Dr. Woldeamanuel, Yimtubezenash | |
| dc.contributor.author | Abebe, Mekdelawit | |
| dc.date.accessioned | 2021-11-14T07:33:42Z | |
| dc.date.accessioned | 2023-11-06T08:10:36Z | |
| dc.date.available | 2021-11-14T07:33:42Z | |
| dc.date.available | 2023-11-06T08:10:36Z | |
| dc.date.issued | 2021-08 | |
| dc.description.abstract | INTRODUCTION:Drug Resistant Tuberculosis is defined as tuberculosis that does not respond to antituberculosis agent. Data on the outcome of MDR/RR-TB and associated factors is highly needed to evaluate the efficiencies of the MDR/ RR-TB treatment program. However, The treatment outcome of MDR/RR-TB at St. Peter Specialized Hospital is not studied. OBJECTIVE: To assess treatment outcomes of MDR/RR-TB and its associated factors at St. Peter Specialized Hospital, Addis Ababa, Ethiopia from 2015 to 2020. METHODS: A retrospective study was conducted among patients treated for drug-resistant tuberculosis from January 2015 - December 2020 at St. Peter specialized hospital. This study included 335 patients treated for multidrug resistant or rifampicine-resistant tuberculosis. The main outcome variable was overall MDR/RR-TB treatment outcome classified as successful and poor. Data were collected by trained nurses. Data entry and analysis were performed using Excel and SPSS. The relationship between MDR/RR-TB treatment outcome and associated factors was evaluated by fitting logistic regression. The final multivariable logistic regression model was a good fit for the data and had no multicollinearity issue. Statistical significance was considered at p<0.05. RESULTS: Treatment success was achieved in 71.3% of the patients. The adjusted odds of poor treatment outcome were twice higher in those who had a habit of frequent alcohol drinking (AOR=2.07, p=0.039). Likewise, the adjusted odds of poor treatment outcome was more than 2folds higher in patients who had a positive result for HIV test. Concerning mortality, the likelihood of death was found to increase by 5% as age advances by one year (AOR=1.05, p<0.001). In addition, the risk of death was more than 3-fold higher among MDR/RR-TB patients co-infected with HIV (AOR=3.81, p<0.001). CONCLUSION: In this study, the overall treatment success was consistent with studies carried out in different regions of Ethiopia. Again, a higher danger of poor treatment outcome and death was observed among people who drink alcohol, co-infected with HIV/AIDS, and the elderly.Patents with MDR/RR-TB patients, use alcohol and are co-infected with HIV/AIDS should be given greater attention during therapy. More studies should be done to generate data on the factors affecting the treatment of MDR/RR-TB patients to improve the outcome of treatment. INTRODUCTION:Drug Resistant Tuberculosis is defined as tuberculosis that does not respond to antituberculosis agent. Data on the outcome of MDR/RR-TB and associated factors is highly needed to evaluate the efficiencies of the MDR/ RR-TB treatment program. However, The treatment outcome of MDR/RR-TB at St. Peter Specialized Hospital is not studied. OBJECTIVE: To assess treatment outcomes of MDR/RR-TB and its associated factors at St. Peter Specialized Hospital, Addis Ababa, Ethiopia from 2015 to 2020. METHODS: A retrospective study was conducted among patients treated for drug-resistant tuberculosis from January 2015 - December 2020 at St. Peter specialized hospital. This study included 335 patients treated for multidrug resistant or rifampicine-resistant tuberculosis. The main outcome variable was overall MDR/RR-TB treatment outcome classified as successful and poor. Data were collected by trained nurses. Data entry and analysis were performed using Excel and SPSS. The relationship between MDR/RR-TB treatment outcome and associated factors was evaluated by fitting logistic regression. The final multivariable logistic regression model was a good fit for the data and had no multicollinearity issue. Statistical significance was considered at p<0.05. RESULTS: Treatment success was achieved in 71.3% of the patients. The adjusted odds of poor treatment outcome were twice higher in those who had a habit of frequent alcohol drinking (AOR=2.07, p=0.039). Likewise, the adjusted odds of poor treatment outcome was more than 2folds higher in patients who had a positive result for HIV test. Concerning mortality, the likelihood of death was found to increase by 5% as age advances by one year (AOR=1.05, p<0.001). In addition, the risk of death was more than 3-fold higher among MDR/RR-TB patients co-infected with HIV (AOR=3.81, p<0.001). CONCLUSION: In this study, the overall treatment success was consistent with studies carried out in different regions of Ethiopia. Again, a higher danger of poor treatment outcome and death was observed among people who drink alcohol, co-infected with HIV/AIDS, and the elderly.Patents with MDR/RR-TB patients, use alcohol and are co-infected with HIV/AIDS should be given greater attention during therapy. More studies should be done to generate data on the factors affecting the treatment of MDR/RR-TB patients to improve the outcome of treatment. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28642 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | MDR-TB, RR-TB ,Tuberculosis, Drug Resistance, Outcome | en_US |
| dc.title | Treatment Outcome of Drug-resistant Tuberculosis and Associated Factors at St.peter Specialized Hospital Addis Ababa, Ethiopia. | en_US |
| dc.type | Thesis | en_US |