Treatment Outcome of Drug-resistant Tuberculosis and Associated Factors at St.peter Specialized Hospital Addis Ababa, Ethiopia.
| dc.contributor.advisor | Hailu Asrat | |
| dc.contributor.advisor | Woldeamanuel Yimtubezenash | |
| dc.contributor.author | Abebe Mekdelawit | |
| dc.date.accessioned | 2021-11-14T07:33:42Z | |
| dc.date.accessioned | 2023-11-06T08:10:36Z | |
| dc.date.available | 2021-11-14T07:33:42Z | |
| dc.date.available | 2023-11-06T08:10:36Z | |
| dc.date.issued | 2021-08 | |
| dc.description.abstract | INTRODUCTION:Drug Resistant Tuberculosis is defined as tuberculosis that does not respondto antituberculosis agent. Data on the outcome of MDR/RR-TB and associated factors is highlyneeded to evaluate the efficiencies of the MDR/ RR-TB treatment program. However, Thetreatment outcome of MDR/RR-TB at St. Peter Specialized Hospital is not studied. OBJECTIVE: To assess treatment outcomes of MDR/RR-TB and its associated factors at St.Peter Specialized Hospital, Addis Ababa, Ethiopia from 2015 to 2020. METHODS: A retrospective study was conducted among patients treated for drug-resistanttuberculosis from January 2015 - December 2020 at St. Peter specialized hospital. This studyincluded 335 patients treated for multidrug resistant or rifampicine-resistant tuberculosis. Themain outcome variable was overall MDR/RR-TB treatment outcome classified as successful andpoor. Data were collected by trained nurses. Data entry and analysis were performed using Exceland SPSS. The relationship between MDR/RR-TB treatment outcome and associated factors wasevaluated by fitting logistic regression. The final multivariable logistic regression model was agood fit for the data and had no multicollinearity issue. Statistical significance was considered atp<0.05. RESULTS: Treatment success was achieved in 71.3% of the patients. The adjusted odds of poortreatment outcome were twice higher in those who had a habit of frequent alcohol drinking(AOR=2.07, p=0.039). Likewise, the adjusted odds of poor treatment outcome was more than 2foldshigher in patients who had a positive result for HIV test. Concerning mortality, thelikelihood of death was found to increase by 5% as age advances by one year (AOR=1.05,p<0.001). In addition, the risk of death was more than 3-fold higher among MDR/RR-TBpatients co-infected with HIV (AOR=3.81, p<0.001). CONCLUSION: In this study, the overall treatment success was consistent with studies carriedout in different regions of Ethiopia. Again, a higher danger of poor treatment outcome and deathwas observed among people who drink alcohol, co-infected with HIV/AIDS, and theelderly.Patents with MDR/RR-TB patients, use alcohol and are co-infected with HIV/AIDSshould be given greater attention during therapy. More studies should be done to generate dataon the factors affecting the treatment of MDR/RR-TB patients to improve the outcome oftreatment. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28642 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | MDR-TB, RR-TB ,Tuberculosis, Drug Resistance, Outcome | en_US |
| dc.title | Treatment Outcome of Drug-resistant Tuberculosis and Associated Factors at St.peter Specialized Hospital Addis Ababa, Ethiopia. | en_US |
| dc.type | Thesis | en_US |