Treatment Outcome of Drug-resistant Tuberculosis and Associated Factors at St.peter Specialized Hospital Addis Ababa, Ethiopia.
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Date
2021-08
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Addis Abeba University
Abstract
INTRODUCTION:Drug Resistant Tuberculosis is defined as tuberculosis that does not respond
to antituberculosis agent. Data on the outcome of MDR/RR-TB and associated factors is highly
needed to evaluate the efficiencies of the MDR/ RR-TB treatment program. However, The
treatment outcome of MDR/RR-TB at St. Peter Specialized Hospital is not studied.
OBJECTIVE: To assess treatment outcomes of MDR/RR-TB and its associated factors at St.
Peter Specialized Hospital, Addis Ababa, Ethiopia from 2015 to 2020.
METHODS: A retrospective study was conducted among patients treated for drug-resistant
tuberculosis from January 2015 - December 2020 at St. Peter specialized hospital. This study
included 335 patients treated for multidrug resistant or rifampicine-resistant tuberculosis. The
main outcome variable was overall MDR/RR-TB treatment outcome classified as successful and
poor. Data were collected by trained nurses. Data entry and analysis were performed using Excel
and SPSS. The relationship between MDR/RR-TB treatment outcome and associated factors was
evaluated by fitting logistic regression. The final multivariable logistic regression model was a
good fit for the data and had no multicollinearity issue. Statistical significance was considered at
p<0.05.
RESULTS: Treatment success was achieved in 71.3% of the patients. The adjusted odds of poor
treatment outcome were twice higher in those who had a habit of frequent alcohol drinking
(AOR=2.07, p=0.039). Likewise, the adjusted odds of poor treatment outcome was more than 2folds
higher in patients who had a positive result for HIV test. Concerning mortality, the
likelihood of death was found to increase by 5% as age advances by one year (AOR=1.05,
p<0.001). In addition, the risk of death was more than 3-fold higher among MDR/RR-TB
patients co-infected with HIV (AOR=3.81, p<0.001).
CONCLUSION: In this study, the overall treatment success was consistent with studies carried
out in different regions of Ethiopia. Again, a higher danger of poor treatment outcome and death
was observed among people who drink alcohol, co-infected with HIV/AIDS, and the
elderly.Patents with MDR/RR-TB patients, use alcohol and are co-infected with HIV/AIDS
should be given greater attention during therapy. More studies should be done to generate data
on the factors affecting the treatment of MDR/RR-TB patients to improve the outcome of
treatment. INTRODUCTION:Drug Resistant Tuberculosis is defined as tuberculosis that does not respond
to antituberculosis agent. Data on the outcome of MDR/RR-TB and associated factors is highly
needed to evaluate the efficiencies of the MDR/ RR-TB treatment program. However, The
treatment outcome of MDR/RR-TB at St. Peter Specialized Hospital is not studied.
OBJECTIVE: To assess treatment outcomes of MDR/RR-TB and its associated factors at St.
Peter Specialized Hospital, Addis Ababa, Ethiopia from 2015 to 2020.
METHODS: A retrospective study was conducted among patients treated for drug-resistant
tuberculosis from January 2015 - December 2020 at St. Peter specialized hospital. This study
included 335 patients treated for multidrug resistant or rifampicine-resistant tuberculosis. The
main outcome variable was overall MDR/RR-TB treatment outcome classified as successful and
poor. Data were collected by trained nurses. Data entry and analysis were performed using Excel
and SPSS. The relationship between MDR/RR-TB treatment outcome and associated factors was
evaluated by fitting logistic regression. The final multivariable logistic regression model was a
good fit for the data and had no multicollinearity issue. Statistical significance was considered at
p<0.05.
RESULTS: Treatment success was achieved in 71.3% of the patients. The adjusted odds of poor
treatment outcome were twice higher in those who had a habit of frequent alcohol drinking
(AOR=2.07, p=0.039). Likewise, the adjusted odds of poor treatment outcome was more than 2folds
higher in patients who had a positive result for HIV test. Concerning mortality, the
likelihood of death was found to increase by 5% as age advances by one year (AOR=1.05,
p<0.001). In addition, the risk of death was more than 3-fold higher among MDR/RR-TB
patients co-infected with HIV (AOR=3.81, p<0.001).
CONCLUSION: In this study, the overall treatment success was consistent with studies carried
out in different regions of Ethiopia. Again, a higher danger of poor treatment outcome and death
was observed among people who drink alcohol, co-infected with HIV/AIDS, and the
elderly.Patents with MDR/RR-TB patients, use alcohol and are co-infected with HIV/AIDS
should be given greater attention during therapy. More studies should be done to generate data
on the factors affecting the treatment of MDR/RR-TB patients to improve the outcome of
treatment.
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Keywords
MDR-TB, RR-TB ,Tuberculosis, Drug Resistance, Outcome